Document Detail


A chitosan-based sinus sealant for reduction of adhesion formation in rabbit and sheep models.
MedLine Citation:
PMID:  22492298     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Chronic sinusitis is the most prevalent chronic disease in the United States in adults aged 18 to 44 years, with approximately 250,000 operations performed annually. Although often successful, sinus surgery fails in greater than 15% of patients. Adhesion formation is a common complication and cause for subsequent revision surgery. Here, the authors evaluate a sprayable chitosan/starch-based sinus sealant and demonstrate its ability to reduce adhesion formation both in vitro and in 2 animal models.
STUDY DESIGN: Randomized, controlled, animal trials.
SETTING: Academic medical center (fibroblast experiments) and animal laboratories (sheep and rabbit studies).
SUBJECTS AND METHODS: This sinus sealant was applied to human cultured fibroblasts obtained from surgically removed polyps to examine its ability to inhibit fibroblast migration and proliferation. The sinus sealant was applied to New Zealand White rabbits (n = 20) in an established cecal-sidewall abrasion model and to sheep (n = 10) in a sinus surgical adhesion model to examine its ability to reduce adhesion formation.
RESULTS: This sinus sealant inhibited migration and proliferation of human cultured fibroblasts and reduced the total adhesion score from 4.9 to 0.3 for a total reduction of 94% (95th percentile confidence interval [CI], 78%, 100%; P < .001) in a well-established rabbit cecal-sidewall model commonly used for adhesion testing. Moreover, this sealant reduced adhesion formation from 80% to 10% for a total reduction of 70% (95th percentile CI, 57%, 93%; P = .003) in a sheep sinus adhesion surgical model.
CONCLUSION: This chitosan-based sealant demonstrates promise for reducing adhesion formation in sinus surgery.
Authors:
Jennifer G Medina; John W Steinke; Subinoy Das
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2012-04-06
Journal Detail:
Title:  Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery     Volume:  147     ISSN:  1097-6817     ISO Abbreviation:  Otolaryngol Head Neck Surg     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-08-01     Completed Date:  2012-10-15     Revised Date:  2013-06-26    
Medline Journal Info:
Nlm Unique ID:  8508176     Medline TA:  Otolaryngol Head Neck Surg     Country:  England    
Other Details:
Languages:  eng     Pagination:  357-63     Citation Subset:  IM    
Affiliation:
Biomaterials Team, Research and Development, Medtronic Surgical Technologies, Jacksonville, Florida, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials*
Chitosan*
Disease Models, Animal
Paranasal Sinuses / surgery*
Rabbits
Sheep
Sinusitis / surgery
Tissue Adhesions / prevention & control*
Tissue Adhesives*
Grant Support
ID/Acronym/Agency:
KL2 RR025754/RR/NCRR NIH HHS; KL2RR025754/RR/NCRR NIH HHS; UL1 TR000090/TR/NCATS NIH HHS
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/Tissue Adhesives; 9012-76-4/Chitosan
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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