Document Detail

Chitin induces accumulation in tissue of innate immune cells associated with allergy.
MedLine Citation:
PMID:  17450126     Owner:  NLM     Status:  MEDLINE    
Allergic and parasitic worm immunity is characterized by infiltration of tissues with interleukin (IL)-4- and IL-13-expressing cells, including T-helper-2 cells, eosinophils and basophils. Tissue macrophages assume a distinct phenotype, designated alternatively activated macrophages. Relatively little is known about the factors that trigger these host responses. Chitin, a widespread environmental biopolymer of N-acetyl-beta-D-glucosamine, provides structural rigidity to fungi, crustaceans, helminths and insects. Here, we show that chitin induces the accumulation in tissue of IL-4-expressing innate immune cells, including eosinophils and basophils, when given to mice. Tissue infiltration was unaffected by the absence of Toll-like-receptor-mediated lipopolysaccharide recognition but did not occur if the injected chitin was pre-treated with the IL-4- and IL-13-inducible mammalian chitinase, AMCase, or if the chitin was injected into mice that overexpressed AMCase. Chitin mediated alternative macrophage activation in vivo and the production of leukotriene B(4), which was required for optimal immune cell recruitment. Chitin is a recognition element for tissue infiltration by innate cells implicated in allergic and helminth immunity and this process can be negatively regulated by a vertebrate chitinase.
Tiffany A Reese; Hong-Erh Liang; Andrew M Tager; Andrew D Luster; Nico Van Rooijen; David Voehringer; Richard M Locksley
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't     Date:  2007-04-22
Journal Detail:
Title:  Nature     Volume:  447     ISSN:  1476-4687     ISO Abbreviation:  Nature     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-03     Completed Date:  2007-05-22     Revised Date:  2014-09-22    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  England    
Other Details:
Languages:  eng     Pagination:  92-6     Citation Subset:  IM    
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MeSH Terms
Basophils / cytology,  immunology
Chitin / immunology*
Eosinophils / cytology,  immunology
Hypersensitivity / immunology*,  parasitology
Immunity, Innate / immunology*
Macrophage Activation
Macrophages / cytology,  immunology
Mice, Inbred BALB C
Mice, Inbred C57BL
Models, Immunological
Receptors, Leukotriene B4 / metabolism
STAT6 Transcription Factor / metabolism
Toll-Like Receptors / deficiency,  genetics
Grant Support
Reg. No./Substance:
0/Ltb4r1 protein, mouse; 0/Receptors, Leukotriene B4; 0/STAT6 Transcription Factor; 0/Stat6 protein, mouse; 0/Toll-Like Receptors; 1398-61-4/Chitin

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