Document Detail

Chitin-glucan, a natural cell scaffold for skin moisturization and rejuvenation.
MedLine Citation:
PMID:  19099547     Owner:  NLM     Status:  MEDLINE    
Two clinical studies were conducted to evaluate the tolerance and effects of a copolymer of chitin and beta-glucan, forming the exoskeleton of fungal cell walls, now supplied for cosmetic applications. A 6-week randomized, double-blind, placebo-controlled study was conducted on 13 volunteers with sensitive skin to compare with 0.5-2% formulations chitin-glucan applied twice daily. Biometrological evaluations showed that erythema did not develop, the water retention capacity of the stratum corneum increased and the transepidermal water loss moderately decreased. Another 16-week randomized, double-blind, placebo-controlled study was conducted on 20 men showing signs of ageing skin. A 1.5% chitin-glucan formulation was applied twice daily. Objective biometrological assessments showed a progressive increase in skin firmness and stratum corneum hydration when desquamation and skin roughness decreased. In conclusion, the chitin-glucan formulations appear safe. They significantly mitigate some signs of skin ageing and improve both stratum corneum hydration and skin barrier function.
S Gautier; E Xhauflaire-Uhoda; P Gonry; G E Piérard
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of cosmetic science     Volume:  30     ISSN:  1468-2494     ISO Abbreviation:  Int J Cosmet Sci     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-22     Completed Date:  2009-02-12     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8007161     Medline TA:  Int J Cosmet Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  459-69     Citation Subset:  IM    
KitoZyme sa, Rue Haute Claire 4, Parc Industriel des Hauts-Sarts, B-4040 Herstal, Belgium.
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MeSH Terms
Chitin / analogs & derivatives*,  pharmacology*
Cosmetics / pharmacology*
Double-Blind Method
Emulsions / pharmacology
Middle Aged
Skin / drug effects*,  metabolism
Skin Aging / drug effects
Water Loss, Insensible / drug effects
beta-Glucans / pharmacology*
Reg. No./Substance:
0/Cosmetics; 0/Emulsions; 0/beta-Glucans; 1398-61-4/Chitin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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