| Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography. | |
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MedLine Citation:
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PMID: 22271616 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25°C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.04-3.87. Chirality, 2012. © 2012 Wiley Periodicals, Inc. |
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Authors:
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Wan Aini Wan Ibrahim; Siti Munirah Abd Wahib; Dadan Hermawan; Mohd Marsin Sanagi; Hassan Y Aboul-Enein |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-24 |
Journal Detail:
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Title: Chirality Volume: - ISSN: 1520-636X ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-24 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8914261 Medline TA: Chirality Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2012 Wiley Periodicals, Inc. |
Affiliation:
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Separation Science and Technology Group (SepSTec), Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia; Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, Johor, Malaysia. wanaini@kimia.fs.utm.my, waini@utm.my. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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