Document Detail

Chiral separation of vinpocetine using cyclodextrin-modified micellar electrokinetic chromatography.
MedLine Citation:
PMID:  22271616     Owner:  NLM     Status:  Publisher    
A cyclodextrin-modified micellar electrokinetic chromatography (CD-MEKC) technique has been developed for enantioseparation of vinpocetine using an inexpensive 2-hydroxypropyl-β-CD (HP-β-CD) as the chiral selector (CS). The best chiral separation was achieved using 40 mM HP-β-CD as the CS in 50 mM phosphate buffer (pH 7.0) consisting of 40 mM sodium dodecyl sulfate (SDS) at a separation temperature and separation voltage of 25°C and 25 kV, respectively. To the author's best knowledge, this is the first CD-MEKC study able to successfully separate the four stereoisomer of vinpocetine in separation time of 9.5 min and resolution of 1.04-3.87. Chirality, 2012. © 2012 Wiley Periodicals, Inc.
Wan Aini Wan Ibrahim; Siti Munirah Abd Wahib; Dadan Hermawan; Mohd Marsin Sanagi; Hassan Y Aboul-Enein
Related Documents :
21769956 - Atmospheric pressure laser ionization (apli) coupled with fourier transform ion cyclotr...
21662926 - Determination of polycyclic aromatic sulfur heterocycles in fossil fuel-related samples.
21773066 - A new validated liquid chromatographic method for the determination of loratadine and i...
22271626 - Development of a validated capillary electrophoresis method for enantiomeric purity con...
8331146 - Purification of antifungal lipopeptides by reversed-phase high-performance liquid chrom...
18969856 - Determination of formaldehyde in shiitake mushroom by ionic liquid-based liquid-phase m...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-1-24
Journal Detail:
Title:  Chirality     Volume:  -     ISSN:  1520-636X     ISO Abbreviation:  -     Publication Date:  2012 Jan 
Date Detail:
Created Date:  2012-1-24     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8914261     Medline TA:  Chirality     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Separation Science and Technology Group (SepSTec), Department of Chemistry, Faculty of Science, Universiti Teknologi Malaysia, Johor, Malaysia; Ibnu Sina Institute for Fundamental Science Studies, Universiti Teknologi Malaysia, Johor, Malaysia.,
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immobilization of lipase B from Candida antarctica on porous styrene-divinylbenzene beads improves b...
Next Document:  What was hot at the ICS meeting Glasgow, Scotland, 2011.