Document Detail


Chiral resolution of tryptophan derivatives by CE using canine serum albumin and bovine serum albumin as chiral selectors.
MedLine Citation:
PMID:  17136718     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This work deals with the application of BSA and canine serum albumin (CSA) for enantioseparation of tryptophan derivatives with CE. The aim of this work was the investigation of the influence of different functional groups of tryptophan derivatives on enantioseparation. CSA as a chiral selector was tested to compare its selector properties with those of BSA. The enantiomers of the tryptophan derivatives were separated by adding BSA or CSA to the BGE. The influence of pH, temperature, BSA and CSA concentration and organic modifiers was investigated. It was found that the stereoselectivity for the different tryptophan derivatives is dependent on the albumin species. It turned out that the different functional groups of the derivatives showed a significant influence on stereoselectivity.
Authors:
Heike Hödl; Julia Koidl; Martin G Schmid; Gerald Gübitz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Electrophoresis     Volume:  27     ISSN:  0173-0835     ISO Abbreviation:  Electrophoresis     Publication Date:  2006 Dec 
Date Detail:
Created Date:  2006-12-04     Completed Date:  2007-03-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  4755-62     Citation Subset:  IM    
Affiliation:
Institute of Pharmaceutical Sciences, Department of Pharmaceutical Chemistry, Karl-Franzens University, Graz, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Cattle
Dogs
Electrophoresis, Capillary / methods*
Hydrogen-Ion Concentration
Serum Albumin / chemistry*
Serum Albumin, Bovine / chemistry*
Stereoisomerism
Tryptophan / analogs & derivatives*,  chemistry,  isolation & purification*
Chemical
Reg. No./Substance:
0/Serum Albumin; 0/Serum Albumin, Bovine; 73-22-3/Tryptophan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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