Document Detail


Chiral ligand-exchange chromatography of amino acids using porous graphitic carbon coated with a dinaphthyl derivative of neamine.
MedLine Citation:
PMID:  18998115     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In this paper, we describe the preparation and the evaluation of a porous graphitic carbon (PGC) column coated with a new dinaphthyl derivative of neamine for chiral ligand-exchange (LE) chromatography. It was shown that the graphitic surface/dinaphthyl anchor system efficiently (1.15 micromol/m(2)) and stably (three months of intensive use) adsorbs the neamine template onto the chromatographic support. The resulting coated PGC stationary phase showed appreciable LE-based enantioselective properties towards several native amino acids.
Authors:
Mustapha Zaher; Corinne Ravelet; Isabelle Baussanne; Anne Ravel; Catherine Grosset; Jean-Luc Décout; Eric Peyrin
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Publication Detail:
Type:  Journal Article     Date:  2008-11-09
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  393     ISSN:  1618-2650     ISO Abbreviation:  Anal Bioanal Chem     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-12-19     Completed Date:  2009-02-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  655-60     Citation Subset:  IM    
Affiliation:
Département de Pharmacochimie Moléculaire UMR 5063 CNRS, Institut de Chimie Moléculaire de Grenoble FR 2607, Université Grenoble I (Joseph Fourier), UFR de Pharmacie, 38041, Grenoble cedex 9, France.
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / analysis*
Chromatography, High Pressure Liquid / methods*
Framycetin / analogs & derivatives*,  chemical synthesis,  chemistry
Graphite / chemistry*
Ligands
Molecular Structure
Porosity
Stereoisomerism
Surface Properties
Time Factors
Chemical
Reg. No./Substance:
0/3',6-di-O-2-methylnaphthalene-neamine; 0/Amino Acids; 0/Ligands; 119-04-0/Framycetin; 7782-42-5/Graphite

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