Document Detail


Chiral discrimination and interaction mechanism between enantiomers and serum albumins.
MedLine Citation:
PMID:  23456739     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
The chiral discrimination studies of biological system are theoretically and practically significant for the development of chiral drugs and life science. Our work has embarked upon the interaction between serum albumin (SA) (including human SA and bovine SA), R,S-1-(4-methoxyphenyl)ethylamine, and R,S-1-(3-methoxyphenyl)ethylamine. The formation of intermediate transition state, binding sites, and chiral discrimination ability can be investigated by ultraviolet-visible spectra and fluorescence spectra. Moreover, both the changes of hydrophobic microenvironment and energy transfer can be detected by synchronous fluorescence spectra and fluorescence lifetime. Copyright © 2013 John Wiley & Sons, Ltd.
Authors:
Zhili Fang; Wencui Su; Weiguang Zhang; Yan Xu; Yajin Xiong; Miaoli Luo; Jun Fan; Xia Yin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of molecular recognition : JMR     Volume:  26     ISSN:  1099-1352     ISO Abbreviation:  J. Mol. Recognit.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-03-04     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9004580     Medline TA:  J Mol Recognit     Country:  England    
Other Details:
Languages:  eng     Pagination:  161-4     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 John Wiley & Sons, Ltd.
Affiliation:
School of Chemistry and Environment, South China Normal University, Guangzhou, 510006, China; School of Basic Science, East China Jiaotong University, Nanchang, 330013, China.
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