| Chiral aspects of the human metabolism of ethosuximide. | |
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MedLine Citation:
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PMID: 15931663 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ethosuximide is a chiral drug substance primarily indicated for the treatment of absence seizures. This drug is used clinically as the racemate. The human urinary metabolites of ethosuximide (I) have been studied using chiral gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). The metabolites identified were the previously reported unchanged ethosuximide (I) enantiomers, all four stereoisomers of 2-(1-hydroxyethyl)-2-methylsuccinimide (II), and the four stereoisomers of 2-ethyl-3-hydroxy-2-methylsuccinimide (III). Through chemical derivatization methodology and GC/MS (using electron impact ionization [EI] and chemical ionization [CI] techniques) two enantiomers of a previously unreported metabolite of ethosuximide, 2-ethyl-2-hydroxymethylsuccinimide (VI), have been identified. |
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Authors:
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J S Millership; J Mifsud; D Galea; W C McRoberts; J T G Hamilton |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biopharmaceutics & drug disposition Volume: 26 ISSN: 0142-2782 ISO Abbreviation: Biopharm Drug Dispos Publication Date: 2005 Sep |
Date Detail:
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Created Date: 2005-08-29 Completed Date: 2005-12-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7911226 Medline TA: Biopharm Drug Dispos Country: England |
Other Details:
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Languages: eng Pagination: 225-32 Citation Subset: IM |
Copyright Information:
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Copyright 2005 John Wiley & Sons, Ltd |
Affiliation:
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Clinical and Practice Research Group, The School of Pharmacy, Medical Biology Centre, The Queen's University of Belfast, 97 Lisburn Road, Belfast BT9 7BL, Northern Ireland. j.millership@qub.ac.uk |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anticonvulsants
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metabolism* Ethosuximide / metabolism* Gas Chromatography-Mass Spectrometry Humans |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 77-67-8/Ethosuximide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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