| Chiral Selective Transmembrane Transport of Amino Acid through Artificial Channels. | |
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MedLine Citation:
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PMID: 23362942 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Peptide-appended pillar[n]arene (n = 5, 6) derivatives have been synthesized. 1H NMR and IR studies reveal that the molecules adopt a tubular conformation in solution and lipid bilayer membranes. Kinetic measurements using the fluorescent labeling method with lipid vesicles reveals that these molecules can efficiently mediate the transport of amino acids across lipid membranes at a very low channel-to-lipid ratio (EC50 = 0.002 mol%) and, in several cases, chiral selectivity for amino acid enantiomers can be achieved, which features one of the key functions of natural amino acid channels. |
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Authors:
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Lei Chen; Wen Si; Liang Zhang; Gangfeng Tang; Zhan-Ting Li; Jun-Li Hou |
Publication Detail:
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Type: JOURNAL ARTICLE Date: 2013-1-30 |
Journal Detail:
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Title: Journal of the American Chemical Society Volume: - ISSN: 1520-5126 ISO Abbreviation: J. Am. Chem. Soc. Publication Date: 2013 Jan |
Date Detail:
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Created Date: 2013-1-31 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7503056 Medline TA: J Am Chem Soc Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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