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Chiral Selective Transmembrane Transport of Amino Acid through Artificial Channels.
MedLine Citation:
PMID:  23362942     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Peptide-appended pillar[n]arene (n = 5, 6) derivatives have been synthesized. 1H NMR and IR studies reveal that the molecules adopt a tubular conformation in solution and lipid bilayer membranes. Kinetic measurements using the fluorescent labeling method with lipid vesicles reveals that these molecules can efficiently mediate the transport of amino acids across lipid membranes at a very low channel-to-lipid ratio (EC50 = 0.002 mol%) and, in several cases, chiral selectivity for amino acid enantiomers can be achieved, which features one of the key functions of natural amino acid channels.
Authors:
Lei Chen; Wen Si; Liang Zhang; Gangfeng Tang; Zhan-Ting Li; Jun-Li Hou
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-30
Journal Detail:
Title:  Journal of the American Chemical Society     Volume:  -     ISSN:  1520-5126     ISO Abbreviation:  J. Am. Chem. Soc.     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7503056     Medline TA:  J Am Chem Soc     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
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