| The Chiptip: a novel tool for automated patch clamp. | |
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MedLine Citation:
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PMID: 19149493 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 microL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria. |
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Authors:
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Albrecht Lepple-Wienhues; Dirck Lassen; Alexander Hümmer; Uwe Czubayko; Martina Knirsch; Andjelko Golubovic |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Combinatorial chemistry & high throughput screening Volume: 12 ISSN: 1875-5402 ISO Abbreviation: Comb. Chem. High Throughput Screen. Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2009-01-19 Completed Date: 2009-03-23 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9810948 Medline TA: Comb Chem High Throughput Screen Country: Netherlands |
Other Details:
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Languages: eng Pagination: 73-7 Citation Subset: IM |
Affiliation:
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Flyion GmbH, Waldhäuserstr. 64, D-72076 Tübingen, Germany. info@flyion.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Automation Bacteria / drug effects Cells / drug effects Cells, Cultured Drug Evaluation, Preclinical / instrumentation*, methods Equipment Design Patch-Clamp Techniques / instrumentation* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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