Document Detail

The Chiptip: a novel tool for automated patch clamp.
MedLine Citation:
PMID:  19149493     Owner:  NLM     Status:  MEDLINE    
To facilitate automated patch clamp measurements of ion channels in cells, the development of an all-glass Chiptip pipette is reported that may be combined with the previously described Flip-the-Tip technology. A single measurement requires less than 50 cells, and the addition of drugs for screening can be limited to very low volumes down to 1 microL. This apparatus is suitable for the study small cells, subcellular organelles and bacteria.
Albrecht Lepple-Wienhues; Dirck Lassen; Alexander Hümmer; Uwe Czubayko; Martina Knirsch; Andjelko Golubovic
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Combinatorial chemistry & high throughput screening     Volume:  12     ISSN:  1875-5402     ISO Abbreviation:  Comb. Chem. High Throughput Screen.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-01-19     Completed Date:  2009-03-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9810948     Medline TA:  Comb Chem High Throughput Screen     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  73-7     Citation Subset:  IM    
Flyion GmbH, Waldhäuserstr. 64, D-72076 Tübingen, Germany.
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MeSH Terms
Bacteria / drug effects
Cells / drug effects
Cells, Cultured
Drug Evaluation, Preclinical / instrumentation*,  methods
Equipment Design
Patch-Clamp Techniques / instrumentation*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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