Document Detail

Chinese medicinal herbs Muh-Shiang Bin-Lang-Wan increases the motility of sphincter of Oddi in anesthetized rabbits through activation of M1 muscarinic receptors.
MedLine Citation:
PMID:  14609730     Owner:  NLM     Status:  MEDLINE    
The sphincter of Oddi (SO) plays an important role in regulating the bile flow into the duodenum. This study was designed to investigate the effect of Chinese Medicinal Herbs Muh-Shiang-Bin-Lang-Wan (MSBLW) and their mechanism of action on regulating the motility of SO in rabbits. The activity of SO in anesthetized rabbits was measured by using a continuously perfused open-tip manometric method. The rabbits were administered with different doses of MSBLW through naso-gastric tubes. The SO motility before and after the administration of MSBLW were recorded, and analyzed with a computer equipped with an off line analysis software. The results showed that the SO activity, in terms of tonic pressure and phasic contraction pressure, were significantly changed. A significant lower tonic pressure and a higher phasic contraction pressure were noticed 40-60 min after administration of MSBLW with a peak response at 0.5-1.0 gm range. The responses were blocked by pretreatment of muscarinic receptors (M1) antagonist, pirenzepine (10 mg/kg, orally). We conclude that MSBLW is effective in increasing the SO motility in rabbits through activation of M1 muscarinic receptors. However, potential application of MSBLW in the treatment of human biliary disorders needs further evaluation.
Yung-ing Kuo; Jen-Hwey Chiu; Jaung-Geng Lin; Chin-Ling Hsieh; Chew-Wun Wu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Life sciences     Volume:  74     ISSN:  0024-3205     ISO Abbreviation:  Life Sci.     Publication Date:  2003 Dec 
Date Detail:
Created Date:  2003-11-11     Completed Date:  2004-01-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0375521     Medline TA:  Life Sci     Country:  England    
Other Details:
Languages:  eng     Pagination:  533-42     Citation Subset:  IM    
Institute of Chinese Medicine Science, China Medical University, Taichung, Taiwan, ROC.
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MeSH Terms
Bile / physiology
Drugs, Chinese Herbal / pharmacology*
Muscarinic Agonists*
Muscarinic Antagonists / pharmacology
Pirenzepine / pharmacology
Plant Extracts / pharmacology
Receptor, Muscarinic M1 / agonists*
Sphincter of Oddi / drug effects*
Reg. No./Substance:
0/Drugs, Chinese Herbal; 0/Muh-Shiang Bin-Lang-Wan; 0/Muscarinic Agonists; 0/Muscarinic Antagonists; 0/Plant Extracts; 0/Receptor, Muscarinic M1; 28797-61-7/Pirenzepine

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