Document Detail


Chinese medicinal herb Radix Astragali suppresses cardiac contractile dysfunction and inflammation in a rat model of autoimmune myocarditis.
MedLine Citation:
PMID:  18782607     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Radix Astragali, a Chinese medicinal herb, consists of polysaccharides and flavonoids as its main active ingredients. It has been widely used for treatment of cardiovascular diseases such as heart failure, angina pectoris, myocardial infarction and stroke in Asian countries. This study was designed to evaluate the effect of Radix Astragali on myocardial dysfunction, cardiac remodeling and morphological alteration in an experimental model of autoimmune myocarditis, a clinical condition often resulting in dilated cardiomyopathy. Experimental autoimmune myocarditis was established with a subcutaneous injection of porcine cardiac myosin into rear footpad in Lewis rats. Radix Astragali treatment was delivered via an intravenous injection (0.2 ml/100g body weight, daily) for 3 weeks. Results from transthoracic echocardiography indicated that experimental autoimmune myocarditis led to impaired myocardial contractile function which was reconciled by Radix Astragali. The experimental autoimmune myocarditis triggered profound inflammation and fibrosis in myocardium as assessed by hematoxylin and eosin (H and E) and Masson's trichrome staining. Interestingly, Radix Astragali significantly attenuated autoimmune myocarditis-induced myocardial inflammation and fibrosis. Similarly, Radix Astragali treatment alleviated autoimmune myocarditis-triggered overt lymphocyte proliferation. Furthermore, Radix Astragali significantly attenuated elevated levels of the Th1 cytokines (IFN-gamma and IL-2), and increased the Th2 cytokines (IL-4 and IL-10) in autoimmune myocarditis. Collectively, our data revealed that Radix Astragali effectively protected against cardiac functional and morphological aberrations in experimental autoimmune myocarditis.
Authors:
Peng Zhao; Guohai Su; Xiaoyan Xiao; Enkui Hao; Xinglei Zhu; Jun Ren
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-20
Journal Detail:
Title:  Toxicology letters     Volume:  182     ISSN:  0378-4274     ISO Abbreviation:  Toxicol. Lett.     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-12-10     Completed Date:  2009-01-09     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7709027     Medline TA:  Toxicol Lett     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  29-35     Citation Subset:  IM    
Affiliation:
Department of Cardiology, Shandong Provincial Hospital, Shandong University, Jinan 250021, PR China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / drug therapy*,  pathology,  physiopathology
Cell Proliferation / drug effects
Cytokines / metabolism
Drugs, Chinese Herbal / chemistry*
Echocardiography
Fibrosis / pathology
Immunohistochemistry
Inflammation / drug therapy*,  pathology
Lymphocytes / drug effects
Male
Myocardial Contraction / drug effects*
Myocarditis / drug therapy*,  pathology,  physiopathology
Myocardium / metabolism
Myosins / metabolism
Plant Extracts / pharmacology
Rats
Rats, Inbred Lew
Th1 Cells / drug effects,  metabolism
Th2 Cells / drug effects,  metabolism
Chemical
Reg. No./Substance:
0/Cytokines; 0/Drugs, Chinese Herbal; 0/Plant Extracts; 0/Radix Astragali seu Hedysari; EC 3.6.4.1/Myosins

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