Document Detail

Chinese dumpling scare hits Japan--a case of methamidophos food poisoning.
MedLine Citation:
PMID:  18827448     Owner:  NLM     Status:  MEDLINE    
An outbreak of food poisoning that affected at least ten people in various regions of Japan was traced to exposure to Chinese dumplings contaminated with the organophosphate insecticide Methamidophos. We experienced the most serious case, a five years old girl, who suffered coma. She presented with features of cholinergic overactivity and her serum cholinesterase activity was 9 U/l. We started intravenous treatment with pralidoxime iodide, atropine sulfate, and midazolam. Her symptoms improved gradually and she was discharged on day 25 without any sequelae. Though poisoning attributed to organophosphate insecticides has become less common in recent years, it is even more important to diagnose the problem rapidly based on the characteristic symptoms and to start specific treatment at the earliest possible stage after poisoning.
Yuka Sumi; Yasumasa Oode; Hiroshi Tanaka
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Publication Detail:
Type:  Letter    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  33     ISSN:  1880-3989     ISO Abbreviation:  J Toxicol Sci     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-01     Completed Date:  2009-01-16     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  485-6     Citation Subset:  IM    
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MeSH Terms
Atropine / therapeutic use
Child, Preschool
Coma / chemically induced,  etiology
Foodborne Diseases / drug therapy,  epidemiology,  pathology*
Insecticides / poisoning*
Japan / epidemiology
Midazolam / therapeutic use
Organothiophosphorus Compounds / poisoning*
Pralidoxime Compounds / therapeutic use
Reg. No./Substance:
0/Insecticides; 0/Organothiophosphorus Compounds; 0/Pralidoxime Compounds; 10265-92-6/methamidophos; 51-55-8/Atropine; 59467-70-8/Midazolam; 6735-59-7/pralidoxime

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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