| Chinese yellow wine and red wine inhibit matrix metalloproteinase-2 and improve atherosclerotic plaque in LDL receptor knockout mice. | |
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MedLine Citation:
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PMID: 20370796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Our previous study found that Chinese yellow wine could inhibit the production of homocysteine (HCY) induced extracellular matrix metalloproteinase-2 (MMP-2) in the cultured rat vascular smooth muscle cells. Little is known about the relationship between Chinese yellow wine and atherosclerosis or MMP-2 in vivo. Thirty-two LDL Receptor knockout mice on a high-fat and L-methionine diet developed plasma hyperhomocysteinemia and atherosclerosis. They were randomly divided into yellow wine group (n = 8), red wine group (n = 8), ethanol group (n = 8), and control group (n = 8), they were sacrificed after 14 weeks. There were no significant differences with plasma total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C), alanine aminotransferase (ALT), and aspartate aminotransferase (AST) levels in the four groups. Plasma HCY was significantly decreased in the yellow wine group compared to the other three groups (P < 0.01). Yellow wine and red wine groups significantly reduced the atherosclerosis lesion area compared to ethanol and control groups (P < 0.001). However, there was no significant discrepancy between the yellow wine group and red wine group. Compared to the control group and ethanol group, the production of MMP-2 reduced 26.8% and 23.6% in the aortic sinus and the activation of MMP-2 reduced 32.6% and 27.3% in the aortic arch in the yellow wine group; the production of MMP-2 reduced 25.7% and 22.4% in the aortic sinus and the activation of MMP-2 reduced 30.2% and 26.6% in the aortic arch in the red wine group. These results suggest that Chinese yellow wine and red wine can inhibit MMP-2 and improve atherosclerosis, and maybe both Chinese yellow wine and red wine have beneficial effects on cardiovascular disease by inhibiting MMP-2. |
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Authors:
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Hangyuan Guo; Longbin Liu; Yafei Shi; Aijing Sun; Fukang Xu; Jufang Chi; Dilai Huang |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-31 |
Journal Detail:
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Title: Cardiovascular therapeutics Volume: 28 ISSN: 1755-5922 ISO Abbreviation: Cardiovasc Ther Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-06-18 Completed Date: 2010-09-27 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101319630 Medline TA: Cardiovasc Ther Country: England |
Other Details:
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Languages: eng Pagination: 161-8 Citation Subset: IM |
Affiliation:
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Department of Cardiology, Shaoxing People's Hospital, the First Affiliated Hospital of Shaoxing University, Zhejiang, 312000 China. ghangyuan@hotmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Alanine Transaminase
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blood Animals Aortic Diseases / drug therapy*, enzymology, genetics, pathology Aspartate Aminotransferases / blood Atherosclerosis / drug therapy*, enzymology, genetics, pathology Biological Markers / blood China Disease Models, Animal Enzyme Activation Homocysteine / blood Lipids / blood Male Matrix Metalloproteinase 2 / antagonists & inhibitors*, metabolism* Mice Mice, Inbred C57BL Mice, Knockout Protease Inhibitors / pharmacology* Receptors, LDL / deficiency*, genetics Wine* |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Lipids; 0/Protease Inhibitors; 0/Receptors, LDL; 454-28-4/Homocysteine; EC 2.6.1.1/Aspartate Aminotransferases; EC 2.6.1.2/Alanine Transaminase; EC 3.4.24.24/Matrix Metalloproteinase 2; EC 3.4.24.24/Mmp2 protein, mouse |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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