| A Chinese Herbal Decoction, Modified Yi Guan Jian, Induces Apoptosis in Hepatic Stellate Cells through an ROS-Mediated Mitochondrial/Caspase Pathway. | |
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MedLine Citation:
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PMID: 20976079 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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The Chinese herb modified Yi Guan Jian (mYGJ) is an effective regimen that is usually used in outpatients with chronic liver diseases such as fibrosis and cirrhosis. However, the mechanism for the action of mYGJ on liver fibrosis is not yet clear. In this study, we found that mYGJ induced hepatic stellate cells (HSCs) apoptosis concomitant with the downregulation of Bcl-2 expression and slight elevation of Bax level. Moreover, the reactive oxygen species (ROS) were generated in the early stages of mYGJ-induced HSCs apoptosis to facilitate calcium and cytochrome c release from the mitochondria to cytosol. Subsequently, caspase 9 and caspase 3 were activated. Furthermore, the activation of ER stress-associated caspase 12 in HSCs was also evaluated. Together, we report the first evidence-based study to demonstrate that mYGJ decoction induces HSCs apoptosis through ROS accumulation and the intrinsic apoptosis pathway. These findings provide rationale for further clinical investigation of traditional Chinese medicine recipes against liver fibrosis. |
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Authors:
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Hung-Jen Lin; Ching-Ping Tseng; Chia-Fan Lin; Mei-Huei Liao; Chuan-Mu Chen; Shung-Te Kao; Ju-Chien Cheng |
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Publication Detail:
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Type: Journal Article Date: 2010-09-26 |
Journal Detail:
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Title: Evidence-based complementary and alternative medicine : eCAM Volume: 2011 ISSN: 1741-4288 ISO Abbreviation: Evid Based Complement Alternat Med Publication Date: 2011 |
Date Detail:
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Created Date: 2010-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101215021 Medline TA: Evid Based Complement Alternat Med Country: England |
Other Details:
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Languages: eng Pagination: 459531 Citation Subset: - |
Affiliation:
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School of Chinese Medicine, College of Chinese Medicine, China Medical University, Taichung 404, Taiwan. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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