Document Detail


China Kadoorie Biobank of 0.5 million people: survey methods, baseline characteristics and long-term follow-up.
MedLine Citation:
PMID:  22158673     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Large blood-based prospective studies can provide reliable assessment of the complex interplay of lifestyle, environmental and genetic factors as determinants of chronic disease.
METHODS: The baseline survey of the China Kadoorie Biobank took place during 2004-08 in 10 geographically defined regions, with collection of questionnaire data, physical measurements and blood samples. Subsequently, a re-survey of 25,000 randomly selected participants was done (80% responded) using the same methods as in the baseline. All participants are being followed for cause-specific mortality and morbidity, and for any hospital admission through linkages with registries and health insurance (HI) databases.
RESULTS: Overall, 512,891 adults aged 30-79 years were recruited, including 41% men, 56% from rural areas and mean age was 52 years. The prevalence of ever-regular smoking was 74% in men and 3% in women. The mean blood pressure was 132/79 mmHg in men and 130/77 mmHg in women. The mean body mass index (BMI) was 23.4 kg/m(2) in men and 23.8 kg/m(2) in women, with only 4% being obese (>30 kg/m(2)), and 3.2% being diabetic. Blood collection was successful in 99.98% and the mean delay from sample collection to processing was 10.6 h. For each of the main baseline variables, there is good reproducibility but large heterogeneity by age, sex and study area. By 1 January 2011, over 10,000 deaths had been recorded, with 91% of surviving participants already linked to HI databases.
CONCLUSION: This established large biobank will be a rich and powerful resource for investigating genetic and non-genetic causes of many common chronic diseases in the Chinese population.
Authors:
Zhengming Chen; Junshi Chen; Rory Collins; Yu Guo; Richard Peto; Fan Wu; Liming Li;
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-09-21
Journal Detail:
Title:  International journal of epidemiology     Volume:  40     ISSN:  1464-3685     ISO Abbreviation:  Int J Epidemiol     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-14     Completed Date:  2012-04-17     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  7802871     Medline TA:  Int J Epidemiol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1652-66     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Age Factors
Aged
Blood Pressure
Body Mass Index
Body Weights and Measures
China
Chronic Disease / epidemiology*
Data Collection
Databases, Factual*
Databases, Genetic
Environment
Female
Follow-Up Studies
Genetic Predisposition to Disease
Genetic Testing / statistics & numerical data*
Health Behavior*
Humans
Life Style*
Male
Middle Aged
Prospective Studies
Questionnaires
Residence Characteristics / statistics & numerical data
Rural Population / statistics & numerical data
Sex Factors
Smoking / epidemiology
Socioeconomic Factors
Grant Support
ID/Acronym/Agency:
088158/Z/09/Z//Wellcome Trust; MC_U137686852//Medical Research Council; //British Heart Foundation; //Cancer Research UK; //Medical Research Council
Investigator
Investigator/Affiliation:
Liming Li / ; Zhengming Chen / ; Junshi Chen / ; Rory Collins / ; Fan Wu / ; Richard Peto / ; Zhengming Chen / ; Garry Lancaster / ; Xiaoming Yang / ; Alex Williams / ; Ling Yang / ; Yumei Chang / ; Yu Guo / ; Guoqing Zhao / ; Zheng Bian / ; Lixue Wu / ; Can Hou / ; Zengchang Pang / ; Shaojie Wang / ; Yun Zhang / ; Kui Zhang / ; Silu Liu / ; Zhonghou Zhao / ; Shumei Liu / ; Zhigang Pang / ; Weijia Feng / ; Shuling Wu / ; Liqiu Yang / ; Huili Han / ; Hui He / ; Xianhai Pan / ; Shanqing Wang / ; Hongmei Wang / ; Xinhua Hao / ; Chunxing Chen / ; Shuxiong Lin / ; Xiaoshu Hu / ; Minghao Zhou / ; Ming Wu / ; Yeyuan Wang / ; Yihe Hu / ; Liangcai Ma / ; Renxian Zhou / ; Guanqun Xu / ; Baiqing Dong / ; Naying Chen / ; Ying Huang / ; Mingqiang Li / ; Jinhuai Meng / ; Zhigao Gan / ; Jiujiu Xu / ; Yun Liu / ; Xianping Wu / ; Yali Gao / ; Ningmei Zhang / ; Guojin Luo / ; Xiangsan Que / ; Xiaofang Chen / ; Pengfei Ge / ; Jian He / ; Xiaolan Ren / ; Hui Zhang / ; Enke Mao / ; Guanzhong Li / ; Zhongxiao Li / ; Jun He / ; Guohua Liu / ; Baoyu Zhu / ; Gang Zhou / ; Shixian Feng / ; Yulian Gao / ; Tianyou He / ; Li Jiang / ; Jianhua Qin / ; Huarong Sun / ; Liqun Liu / ; Min Yu / ; Yaping Chen / ; Zhixiang Hu / ; Jianjin Hu / ; Yijian Qian / ; Zhiying Wu / ; Lingli Chen / ; Wen Liu / ; Guangchun Li / ; Huilin Liu / ; Xiangquan Long / ; Youping Xiong / ; Zhongwen Tan / ; Xuqiu Xie / ; Yunfang Peng /
Comments/Corrections

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