Document Detail


Chimerism in systemic lupus erythematosus--three hypotheses.
MedLine Citation:
PMID:  17135226     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Systemic lupus erythematosus (SLE) is an immune-mediated disease characterized by the presence of autoantibodies and a wide array of clinical symptoms. Despite intensive research, the aetiology of SLE is still unknown and is probably multifactorial. Both genetic and environmental factors have been associated with SLE, but these factors alone are insufficient to explain the onset of SLE. Recently, it has been suggested that chimerism plays a role in the pathogenesis of autoimmune diseases, including SLE. Chimerism indicates the presence of cells from one individual in another individual. In an experimental mouse model, the injection of chimeric cells induces a lupus-like disease. In addition, chimerism is found more often in kidneys of women with SLE than in healthy controls. There are several mechanisms by which chimeric cells could be involved in the pathogenesis of SLE. In this review, three hypotheses on the role of chimerism in SLE are discussed. The first two hypotheses describe the possibilities that chimeric cells induce either a graft-vs-host reaction in the host (comparable with reactions seen after bone marrow transplantation) or a host-vs-graft reaction (comparable with reactions seen after solid organ transplantation). The third hypothesis discusses the possible beneficial role chimeric cells may play in repair mechanisms due to their stem cell-like properties. This review provides insights into the mechanisms by which chimerism may be involved in SLE and proposes several lines of inquiry to further investigate chimerism in SLE.
Authors:
I C L Kremer Hovinga; M Koopmans; E de Heer; J A Bruijn; I M Bajema
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2006-11-29
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  46     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-01-23     Completed Date:  2007-03-30     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  England    
Other Details:
Languages:  eng     Pagination:  200-8     Citation Subset:  AIM; IM    
Affiliation:
Department of Pathology, Leiden University Medical Center, P0-14, PO Box 9600, 2300 RC Leiden, The Netherlands. i.c.l.kremer-hovinga@lumc.nl
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MeSH Terms
Descriptor/Qualifier:
Animals
Autoimmune Diseases / genetics,  immunology
Chimerism*
Graft vs Host Reaction / genetics
Host vs Graft Reaction / genetics
Humans
Lupus Erythematosus, Systemic / genetics*,  immunology
Mice
Regeneration / genetics

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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