Document Detail

Children with genetic disorders undergoing open-heart surgery: Are they at increased risk for postoperative complications?
MedLine Citation:
PMID:  21057364     Owner:  NLM     Status:  In-Data-Review    
OBJECTIVES: : Children with congenital heart disease and genetic disorders may be at increased risk for postoperative mortality and morbidity compared with children with congenital heart disease alone. The aim of the present study was to determine differences in postcardiopulmonary bypass outcome between these two groups.
DESIGN: : Prospective cohort study.
SETTING: : Tertiary university children's hospital.
PATIENTS: : We enrolled 211 infants (<1 yr) who underwent bypass surgery for congenital heart disease. Data on perioperative course were compared between infants with and without genetic disorders. Univariate analysis was followed by regression analysis to control for confounders.
MEASUREMENTS AND MAIN RESULTS: : We enrolled 148 infants without and 63 infants with a genetic disorder. The majority of infants with genetic disorders had trisomy 21 (n = 32), six had microdeletion 22q11, and 25 had other genetic disorders. There was no significant difference in mortality between infants with and without genetic disorders. An underlying genetic disorder was an independent risk factor for renal insufficiency (p = .003) and reintubation (p = .02). Trisomy 21 was an independent risk factor for chylothorax (p = .01) and sepsis (p = .05). The length of hospital stay was longer in infants with genetic disorders other than trisomy 21 compared with infants with trisomy 21 (p = .009).
CONCLUSIONS: : Infants with congenital heart disease and genetic disorders are not at increased risk for postoperative mortality. However, a genetic disorder is a risk factor for reintubation and renal insufficiency, whereas infants with trisomy 21 have a higher risk of chylothorax and sepsis. Intensive care providers need to be aware of these differences in morbidity to improve management decisions and parental counseling.
Carsten Doell; Vera Bernet; Luciano Molinari; Ingrid Beck; Christian Balmer; Beatrice Latal
Related Documents :
7645384 - Abnormal cardiac histology in severe intrauterine growth retardation infants.
8941454 - Neonatal lupus.
4087114 - Analysis of neonatal heart rate variability by a microprocessor-based on-line system.
12022304 - Bradycardic response during submersion in infant swimming.
9120744 - Prophylaxis of respiratory distress syndrome by treatment with modified porcine surfact...
8632934 - Breastfeeding and the working mother: effect of time and temperature of short-term stor...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric critical care medicine : a journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies     Volume:  12     ISSN:  1529-7535     ISO Abbreviation:  Pediatr Crit Care Med     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954653     Medline TA:  Pediatr Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  539-44     Citation Subset:  IM    
From the Pediatric Intensive Care and Neonatology (CD, VB), the Child Development Center (LM, IB, BL), and Pediatric Cardiology (CB), University Children's Hospital, Zurich, Switzerland.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Toward the inclusion of parents on pediatric critical care unit rounds.
Next Document:  The effect of critical illness and inflammation on midazolam therapy in children*.