Document Detail

Children with cystic fibrosis: who should visit the otorhinolaryngologist?
MedLine Citation:
PMID:  12431163     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Sinonasal complications are common in children with cystic fibrosis (CF). Generally, those children with persistent symptoms of sinonasal polyposis are referred to an otorhinolaryngologic (ORL) physician for sinus surgery. Several studies have reported differences in clinical characteristics between CF patients with and without sinonasal polyps. OBJECTIVES: To predict the presence of sinonasal polyposis in children with CF on the basis of symptoms and clinical characteristics and so to select those children who might benefit from referral to an ORL physician. DESIGN, SETTING, AND PATIENTS: Survey of data from a database on the results of yearly multidisciplinary examinations of 140 children with CF. MAIN OUTCOME MEASURE: Presence of sinonasal polyposis. RESULTS: In the total population of 140 children, no combination of ORL symptoms and clinical characteristics could accurately predict the presence of sinonasal polyposis. In a subgroup of 73 children with a history of nasal symptoms, independent predictors for the presence of sinonasal polyposis were male sex, age 10 years or older, presence of rhinorrhea, and a forced vital capacity 70% or more of the predicted value. The area under the receiver operating characteristic curve of a scoring rule including these independent predictors was 0.77. The positive and negative predictive values of this rule were 0.86 and 0.71, respectively. CONCLUSION: A scoring rule including the independent predictors sex, age, symptoms of rhinorrhea, and forced vital capacity values could reasonably classify children with CF and nasal symptoms into a category with increased risk for sinonasal polyposis, thus facilitating the decision on ORL referral.
Martyn G Slieker; Anne G M Schilder; Cuno S P M Uiterwaal; Cornelis K van der Ent
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archives of otolaryngology--head & neck surgery     Volume:  128     ISSN:  0886-4470     ISO Abbreviation:  Arch. Otolaryngol. Head Neck Surg.     Publication Date:  2002 Nov 
Date Detail:
Created Date:  2002-11-14     Completed Date:  2002-12-09     Revised Date:  2006-03-28    
Medline Journal Info:
Nlm Unique ID:  8603209     Medline TA:  Arch Otolaryngol Head Neck Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1245-8     Citation Subset:  AIM; IM    
Department of Pediatric Pulmonology, Wilhelmina Children's Hospital, University Medical Center Utrecht, The Netherlands.
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MeSH Terms
Age Distribution
Analysis of Variance
Child, Preschool
Cohort Studies
Cystic Fibrosis / diagnosis,  epidemiology*
Nasal Polyps / diagnosis,  epidemiology*,  surgery*
Otorhinolaryngologic Surgical Procedures / methods
Paranasal Sinus Neoplasms / diagnosis,  epidemiology*,  surgery*
Predictive Value of Tests
Risk Assessment
Sex Distribution

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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