Document Detail

Children and adolescents with obesity and the metabolic syndrome have high circulating cortisol levels.
MedLine Citation:
PMID:  18283269     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: The aim of this study was to investigate the relationship between the varying degrees of obesity and blood glucocorticoid levels in obese children and adolescents with and without metabolic syndrome features. METHODS: We studied 241 obese children and adolescents aged between 2 and 17.6 years; 127 boys and 114 girls. All children underwent an oral glucose tolerance test. Measurements included blood pressure, cortisol, ACTH, and lipid profiles. The diagnosis of metabolic syndrome was defined according to the criteria adapted from World Health Organisation and National Cholesterol Education Program Adult Treatment Panel-III guidelines. RESULTS: Blood cortisol and ACTH levels were higher in patients with MS than without MS (p = 0.02). ACTH levels increased with weight (r = 0.13, p = 0.02), systolic blood pressure (r = 0.21, p = 0.002), diastolic blood pressure (r = 0.17, p = 0.01), fasting glucose (r = 0.17, p = 0.01). Cortisol production was only correlated with systolic blood pressure (r = 0.12, p = 0.05). CONCLUSIONS: Results from the present study indicates that there may be a link between cortisol production and the metabolic syndrome in obese children and adolescents.
Yasar Sen; Denizmen Aygun; Erdal Yilmaz; Ahmet Ayar
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  29     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-06     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Department of Paediatrics, Division of Paediatric Endocrinology, Faculty of Medicine, Firat University, Elazig, Turkey.
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MeSH Terms
Adrenocorticotropic Hormone / blood
Blood Pressure / physiology
Child, Preschool
Hydrocortisone / blood*
Lipids / blood
Metabolic Syndrome X / blood*,  physiopathology
Obesity / blood*,  physiopathology
Risk Factors
Reg. No./Substance:
0/Lipids; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

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