Document Detail


Children and adolescents with obesity and the metabolic syndrome have high circulating cortisol levels.
MedLine Citation:
PMID:  18283269     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: The aim of this study was to investigate the relationship between the varying degrees of obesity and blood glucocorticoid levels in obese children and adolescents with and without metabolic syndrome features. METHODS: We studied 241 obese children and adolescents aged between 2 and 17.6 years; 127 boys and 114 girls. All children underwent an oral glucose tolerance test. Measurements included blood pressure, cortisol, ACTH, and lipid profiles. The diagnosis of metabolic syndrome was defined according to the criteria adapted from World Health Organisation and National Cholesterol Education Program Adult Treatment Panel-III guidelines. RESULTS: Blood cortisol and ACTH levels were higher in patients with MS than without MS (p = 0.02). ACTH levels increased with weight (r = 0.13, p = 0.02), systolic blood pressure (r = 0.21, p = 0.002), diastolic blood pressure (r = 0.17, p = 0.01), fasting glucose (r = 0.17, p = 0.01). Cortisol production was only correlated with systolic blood pressure (r = 0.12, p = 0.05). CONCLUSIONS: Results from the present study indicates that there may be a link between cortisol production and the metabolic syndrome in obese children and adolescents.
Authors:
Yasar Sen; Denizmen Aygun; Erdal Yilmaz; Ahmet Ayar
Related Documents :
12151869 - Emerging concepts in the pathophysiology and treatment of obesity-associated hypertension.
9536919 - Influences on adrenaline-induced thermogenesis in obese women and relationship to cardi...
15586739 - Prevalence of sustained hypertension and obesity in urban and rural school going childr...
7859399 - Hypertension in children and adolescents.
11725159 - Association of body mass index with blood pressure in 80-year-old subjects.
3089519 - The effect of desmopressin on nocturnal polyuria, overnight weight loss, and morning po...
772239 - The influence of increased tubular hydrostatic pressure on renal function.
22212439 - Analysis of various etiologies of hypertension in patients hospitalized in the endocrin...
3733609 - Role of histamine in acute oleic acid-induced lung injury.
Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Neuro endocrinology letters     Volume:  29     ISSN:  0172-780X     ISO Abbreviation:  Neuro Endocrinol. Lett.     Publication Date:  2008 Feb 
Date Detail:
Created Date:  2008-03-06     Completed Date:  2008-04-17     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8008373     Medline TA:  Neuro Endocrinol Lett     Country:  Sweden    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Division of Paediatric Endocrinology, Faculty of Medicine, Firat University, Elazig, Turkey. yasarsen@firat.edu.tr
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenocorticotropic Hormone / blood
Blood Pressure / physiology
Child
Child, Preschool
Female
Humans
Hydrocortisone / blood*
Lipids / blood
Male
Metabolic Syndrome X / blood*,  physiopathology
Obesity / blood*,  physiopathology
Risk Factors
Chemical
Reg. No./Substance:
0/Lipids; 50-23-7/Hydrocortisone; 9002-60-2/Adrenocorticotropic Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Circulating resistin levels are lower in hypothyroid women but independent from thyroid hormones con...
Next Document:  Application of endoscopy in pediatric and adolescent gynecology.