| Childhood-onset HAM/TSP with progressive cognitive impairment. | |
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MedLine Citation:
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PMID: 20076981 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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HTLV-I associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic myelopathy, usually with adult-onset. Very few cases of childhood-onset have been described, most presenting with progressive paraparesis and sphincteric disturbances as in the adult form. Here we report a young male with childhood-onset of HAM/TSP and progressive cognitive and behavioral disturbances. A serological screening revealed HTLV-I infection, confirmed by Western Immunoblotting analysis. Molecular characterization of amplified HTLV-I proviral DNA has been performed both in the patient and his mother by LTR sequence analysis, and HLA genotype inheritance was evaluated. Our case indicates the possibility that cognitive dysfunctions may be one manifestation of HTLV-I infection in childhood. |
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Authors:
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Giovanna Zorzi; Roberta Mancuso; Nardo Nardocci; Laura Farina; Franca Rosa Guerini; Pasquale Ferrante |
Publication Detail:
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Type: Case Reports; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology Volume: 31 ISSN: 1590-3478 ISO Abbreviation: Neurol. Sci. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-03-18 Completed Date: 2010-06-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100959175 Medline TA: Neurol Sci Country: Italy |
Other Details:
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Languages: eng Pagination: 209-12 Citation Subset: IM |
Affiliation:
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Department of Child Neurology, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Age of Onset Brain / pathology Child Child Behavior Disorders / complications, genetics, metabolism Chronic Disease Cognition Disorders / complications*, genetics, metabolism DNA, Viral Disease Progression Fathers Female Genotype HLA Antigens / genetics HTLV-I Infections / complications, genetics, metabolism Haplotypes Humans Male Mothers Paraparesis, Tropical Spastic / complications*, genetics, metabolism Pedigree Young Adult |
| Chemical | |
Reg. No./Substance:
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0/DNA, Viral; 0/HLA Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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