Document Detail

Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment.
MedLine Citation:
PMID:  8599409     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia. METHOD: Eight adolescent patients with onset of psychosis before age 12 and eight matched comparison subjects had initial and 2-year follow-up brain magnetic resonance imaging scans. Basal ganglia and lateral ventricle volumes were measured. The patients were on a clozapine regimen during the 2-year interim. RESULTS: Caudate volume was larger in the patients at the initial scanning, decreased in the patients between scans, and did not differ significantly between the patients and the comparison subjects at the second scanning. CONCLUSIONS: Caudate enlargement in patients with childhood-onset schizophrenia who are taking typical neuroleptics appears to be secondary to medication exposure. Rescanning to examine basal ganglia morphology is indicated for these patients when they are taking an atypical neuroleptic.
J A Frazier; J N Giedd; D Kaysen; K Albus; S Hamburger; J Alaghband-Rad; M C Lenane; K McKenna; A Breier; J L Rapoport
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The American journal of psychiatry     Volume:  153     ISSN:  0002-953X     ISO Abbreviation:  Am J Psychiatry     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-04-24     Completed Date:  1996-04-24     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370512     Medline TA:  Am J Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  564-6     Citation Subset:  AIM; IM    
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA.
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MeSH Terms
Age of Onset
Antipsychotic Agents / pharmacology,  therapeutic use*
Basal Ganglia / anatomy & histology,  drug effects
Brain / anatomy & histology*,  drug effects
Caudate Nucleus / anatomy & histology,  drug effects
Cerebral Ventricles / anatomy & histology,  drug effects
Clozapine / pharmacology,  therapeutic use*
Follow-Up Studies
Magnetic Resonance Imaging*
Putamen / anatomy & histology,  drug effects
Schizophrenia, Childhood / diagnosis*,  drug therapy
Reg. No./Substance:
0/Antipsychotic Agents; 5786-21-0/Clozapine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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