| Childhood-onset schizophrenia: brain MRI rescan after 2 years of clozapine maintenance treatment. | |
| | |
MedLine Citation:
|
PMID: 8599409 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: The effect of clozapine on striatal morphology was examined in adolescents with childhood-onset schizophrenia. METHOD: Eight adolescent patients with onset of psychosis before age 12 and eight matched comparison subjects had initial and 2-year follow-up brain magnetic resonance imaging scans. Basal ganglia and lateral ventricle volumes were measured. The patients were on a clozapine regimen during the 2-year interim. RESULTS: Caudate volume was larger in the patients at the initial scanning, decreased in the patients between scans, and did not differ significantly between the patients and the comparison subjects at the second scanning. CONCLUSIONS: Caudate enlargement in patients with childhood-onset schizophrenia who are taking typical neuroleptics appears to be secondary to medication exposure. Rescanning to examine basal ganglia morphology is indicated for these patients when they are taking an atypical neuroleptic. |
| | |
Authors:
|
J A Frazier; J N Giedd; D Kaysen; K Albus; S Hamburger; J Alaghband-Rad; M C Lenane; K McKenna; A Breier; J L Rapoport |
Related Documents
:
|
7934059 - Spiperone binding capacity in lymphocytes of patients with alcohol- and drug-induced ps... 9300519 - The anthropometric assessment of dysmorphic features in schizophrenia as an index of it... 14997019 - Analysis of il-1alpha, il-1beta, and il-1ra [correction of il-ra] polymorphisms in dyst... 14967549 - Minor physical anomalies in patients with schizophrenia and their parents: prevalence a... 8350789 - Phenomenological differences of hallucinations between schizophrenic patients in penang... 21669119 - Dynamics of nutritional status in dying patients with acute cerebral infarction in cent... 8837259 - The use of ethanol as a marker to detect and quantify the absorption of irrigation flui... 10894879 - Phase i and pharmacokinetic trial of gemcitabine in patients with hepatic or renal dysf... 6537469 - Atypical nonketotic hyperglycinemia with a defective glycine transport system in nervou... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The American journal of psychiatry Volume: 153 ISSN: 0002-953X ISO Abbreviation: Am J Psychiatry Publication Date: 1996 Apr |
Date Detail:
|
Created Date: 1996-04-24 Completed Date: 1996-04-24 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0370512 Medline TA: Am J Psychiatry Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 564-6 Citation Subset: AIM; IM |
Affiliation:
|
Child Psychiatry Branch, NIMH, Bethesda, MD 20892, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Age of Onset Antipsychotic Agents / pharmacology, therapeutic use* Basal Ganglia / anatomy & histology, drug effects Brain / anatomy & histology*, drug effects Caudate Nucleus / anatomy & histology, drug effects Cerebral Ventricles / anatomy & histology, drug effects Child Clozapine / pharmacology, therapeutic use* Female Follow-Up Studies Humans Magnetic Resonance Imaging* Male Putamen / anatomy & histology, drug effects Schizophrenia, Childhood / diagnosis*, drug therapy |
| Chemical | |
Reg. No./Substance:
|
0/Antipsychotic Agents; 5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: A comparative study of Vietnamese Amerasians, their non-Amerasian siblings, and unrelated, like-aged...
Next Document: Sebomatricoma: a unifying term that encompasses all benign neoplasms with sebaceous differentiation.