Document Detail

Childhood neurobehavior disinhibition amplifies the risk of substance use disorder: interaction of parental history and prenatal alcohol exposure.
MedLine Citation:
PMID:  17565289     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: This investigation examined the influence of parental substance use disorder (SUD) and mother's alcohol consumption during pregnancy on neurobehavior disinhibition (ND) measured in 10- to 12-year-old children. The extent to which ND predicted SUD outcome 7 to 9 years later was also determined. METHODS: SUD was documented in each parent and as the outcome variable in their 19-year-old sons. Average daily alcohol consumption during the mother's pregnancy was recorded using a structured interview. ND was assessed using indicators of behavior undercontrol, affect modulation and executive cognitive functions. RESULTS: Paternal SUD and the interaction between maternal SUD and alcohol consumption during pregnancy predicted child's ND score. ND at 10 to 12 years of age was a significant predictor of SUD at age 19. CONCLUSIONS: The disinhibitory disturbance associated with risk of SUD has both transmissible and teratogenic causes. The ramifications of this finding for pediatric practice are discussed.
Kim Chapman; Ralph E Tarter; Levent Kirisci; Marie D Cornelius
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Journal of developmental and behavioral pediatrics : JDBP     Volume:  28     ISSN:  0196-206X     ISO Abbreviation:  J Dev Behav Pediatr     Publication Date:  2007 Jun 
Date Detail:
Created Date:  2007-06-13     Completed Date:  2007-09-04     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  8006933     Medline TA:  J Dev Behav Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  219-24     Citation Subset:  IM    
Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA.
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MeSH Terms
Affect / drug effects
Alcohol-Related Disorders*
Child of Impaired Parents*
Cognition / drug effects
Cohort Studies
Diagnosis, Dual (Psychiatry)
Family Health
Follow-Up Studies
Impulsive Behavior / complications*
Inhibition (Psychology)*
Neuropsychological Tests
Personality Disorders / complications
Prenatal Exposure Delayed Effects*
Regression Analysis
Risk Factors
Severity of Illness Index
Substance-Related Disorders / complications,  prevention & control*,  psychology
Grant Support

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