| Childhood neurobehavior disinhibition amplifies the risk of substance use disorder: interaction of parental history and prenatal alcohol exposure. | |
| | |
MedLine Citation:
|
PMID: 17565289 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVE: This investigation examined the influence of parental substance use disorder (SUD) and mother's alcohol consumption during pregnancy on neurobehavior disinhibition (ND) measured in 10- to 12-year-old children. The extent to which ND predicted SUD outcome 7 to 9 years later was also determined. METHODS: SUD was documented in each parent and as the outcome variable in their 19-year-old sons. Average daily alcohol consumption during the mother's pregnancy was recorded using a structured interview. ND was assessed using indicators of behavior undercontrol, affect modulation and executive cognitive functions. RESULTS: Paternal SUD and the interaction between maternal SUD and alcohol consumption during pregnancy predicted child's ND score. ND at 10 to 12 years of age was a significant predictor of SUD at age 19. CONCLUSIONS: The disinhibitory disturbance associated with risk of SUD has both transmissible and teratogenic causes. The ramifications of this finding for pediatric practice are discussed. |
| | |
Authors:
|
Kim Chapman; Ralph E Tarter; Levent Kirisci; Marie D Cornelius |
Related Documents
:
|
20436309 - Pulmonary imaging during pregnancy. 3631169 - Cocaine use during pregnancy: adverse perinatal outcome. 17428259 - Association of maternal fat and alcohol intake with maternal and umbilical hormone leve... 8589089 - The association of moderate maternal and paternal alcohol consumption with birthweight ... 19394419 - Moderate use of alcohol, tobacco and cannabis during pregnancy: new approaches and upda... 3763069 - Selenium in pregnancy: effect of maternal drinking. 22170519 - Female perceptions of male versus female intendedness at the time of teenage pregnancy. 3309249 - Watchful waiting of a fetus with zone iii amniotic fluid values. 22115959 - The progesterone receptor regulates implantation, decidualization, and glandular develo... |
Publication Detail:
|
Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
|
Title: Journal of developmental and behavioral pediatrics : JDBP Volume: 28 ISSN: 0196-206X ISO Abbreviation: J Dev Behav Pediatr Publication Date: 2007 Jun |
Date Detail:
|
Created Date: 2007-06-13 Completed Date: 2007-09-04 Revised Date: 2007-12-03 |
Medline Journal Info:
|
Nlm Unique ID: 8006933 Medline TA: J Dev Behav Pediatr Country: United States |
Other Details:
|
Languages: eng Pagination: 219-24 Citation Subset: IM |
Affiliation:
|
Department of Pediatrics, University of Pittsburgh Medical Center, Pittsburgh, PA 15261, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adolescent Adult Affect / drug effects Alcohol-Related Disorders* Child Child of Impaired Parents* Cognition / drug effects Cohort Studies Diagnosis, Dual (Psychiatry) Family Health Fathers Female Follow-Up Studies Humans Impulsive Behavior / complications* Inhibition (Psychology)* Male Mothers Neuropsychological Tests Personality Disorders / complications Pregnancy Prenatal Exposure Delayed Effects* Regression Analysis Risk Factors Severity of Illness Index Substance-Related Disorders / complications, prevention & control*, psychology |
| Grant Support | |
ID/Acronym/Agency:
|
K02 DA017822/DA/NIDA NIH HHS; P50 DA05605/DA/NIDA NIH HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: "Care for Development" intervention in rural China: a prospective follow-up study.
Next Document: Behavioral inhibition in preschool children at risk is a specific predictor of middle childhood soci...