| Childhood moyamoya disease: quantitative evaluation of perfusion MR imaging--correlation with clinical outcome after revascularization surgery. | |
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MedLine Citation:
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PMID: 19332853 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: To evaluate whether perfusion magnetic resonance (MR) imaging can depict hemodynamic status after revascularization surgery and whether changes at perfusion MR imaging after revascularization surgery correspond with clinical outcome in moyamoya disease. MATERIALS AND METHODS: An institutional review board approved this retrospective study; informed consent was waived. Pre- and postoperative perfusion MR imaging data in 67 children with moyamoya disease (mean age, 7.2 years; range, 2-13 years) were included. Regional time to peak (rTTP) and regional cerebral blood volume (rCBV) were calculated by adjusting cerebral time to peak (TTP) and cerebral blood volume (CBV) values by using cerebellar reference values. For quantitative regional analysis, pixel values were divided into five categories (>0, >2, >4, >6, and >8 seconds), and percentages of pixels in rTTP meeting these time conditions were calculated. Changes in the values after revascularization were calculated. Postoperative clinical outcomes were categorized as follows: 1 indicated excellent; 2, good; 3, fair; and 4, poor. Pre- and postoperative perfusion parameters were compared by using a paired t test; relationships between perfusion parameters and clinical outcomes were investigated by using one-way analysis of variance, with a significance level of .05. RESULTS: rTTP, rCBV, and percentage of pixels of rTTP decreased significantly after revascularization surgery. Pre- and postoperative rTTP were significantly different for the clinical outcome categories. Change in rTTP and change in percentage of pixels of rTTP (>0 seconds to >6 seconds) were significantly different for the clinical outcome categories. CONCLUSION: TTP and CBV perfusion maps can depict hemodynamic status after revascularization surgery in moyamoya disease. Furthermore, changes in TTP perfusion maps after revascularization surgery correspond with clinical outcome in patients with moyamoya disease. |
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Authors:
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Tae Jin Yun; Jung-Eun Cheon; Dong Gyu Na; Woo Sun Kim; In-One Kim; Kee-Hyun Chang; Kyung Mo Yeon; In Chan Song; Kyu-Chang Wang |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Radiology Volume: 251 ISSN: 1527-1315 ISO Abbreviation: Radiology Publication Date: 2009 Apr |
Date Detail:
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Created Date: 2009-03-31 Completed Date: 2009-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: United States |
Other Details:
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Languages: eng Pagination: 216-23 Citation Subset: AIM; IM |
Affiliation:
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Department of Radiology, Seoul National University Hospital, 101 Daehangno, Jongno-gu, Seoul 110-744, Korea. |
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| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Algorithms* Brain / blood supply, pathology* Cerebral Revascularization / methods* Cerebrovascular Circulation Child Child, Preschool Female Humans Image Enhancement / methods Image Interpretation, Computer-Assisted / methods* Male Moyamoya Disease / diagnosis*, surgery* Reproducibility of Results Retrospective Studies Sensitivity and Specificity Statistics as Topic Treatment Outcome |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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