| Childhood leukemia around French nuclear power plants--the Geocap study, 2002-2007. | |
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MedLine Citation:
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PMID: 22223329 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The aim of this work is to study the risk of childhood acute leukemia (AL) around French nuclear power plants (NPPs). The nationwide Geocap case-control study included the 2,753 cases diagnosed in mainland France over 2002-2007 and 30,000 contemporaneous population controls. The last addresses were geocoded and located around the 19 NPPs. The study used distance to NPPs and a dose-based geographic zoning (DBGZ), based on the estimated dose to bone marrow related to NPP gaseous discharges. An odds ratio (OR) of 1.9 [1.0-3.3], based on 14 cases, was evidenced for children living within 5 km of NPPs compared to those living 20 km or further away, and a very similar association was observed in the concomitant incidence study (standardized incidence ratio (SIR)=1.9 [1.0-3.2]). These results were similar for all the 5-year-age groups. They persisted after stratification for several contextual characteristics of the municipalities of residence. Conversely, using the DBGZ resulted in OR and SIR close to one in all of the dose categories. There was no increase in AL incidence over 1990-2001 and over the entire 1990-2007 period. The results suggest a possible excess risk of AL in the close vicinity of French NPPs in 2002-2007. The absence of any association with the DBGZ may indicate that the association is not explained by NPP gaseous discharges. Overall, the findings call for investigation for potential risk factors related to the vicinity of NPP and collaborative analysis of multisite studies conducted in various countries. |
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Authors:
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Claire Sermage-Faure; Dominique Laurier; Stéphanie Goujon-Bellec; Michel Chartier; Aurélie Guyot-Goubin; Jérémie Rudant; Denis Hémon; Jacqueline Clavel |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-28 |
Journal Detail:
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Title: International journal of cancer. Journal international du cancer Volume: 131 ISSN: 1097-0215 ISO Abbreviation: Int. J. Cancer Publication Date: 2012 Sep |
Date Detail:
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Created Date: 2012-06-28 Completed Date: 2012-09-20 Revised Date: 2012-12-18 |
Medline Journal Info:
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Nlm Unique ID: 0042124 Medline TA: Int J Cancer Country: United States |
Other Details:
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Languages: eng Pagination: E769-80 Citation Subset: IM |
Copyright Information:
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Copyright © 2012 UICC. |
Affiliation:
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INSERM U1018, CESP Center for research in Epidemiology and Population Health, Environmental Epidemiology of Cancer Team, Villejuif F-94807, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Case-Control Studies Child Child, Preschool Cohort Studies Environmental Exposure / adverse effects* Female Follow-Up Studies France / epidemiology Humans Incidence Infant Infant, Newborn Leukemia / epidemiology, etiology* Male Nuclear Power Plants Prognosis Residence Characteristics Risk Factors Survival Rate |
| Comments/Corrections | |
Comment In:
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Int J Cancer. 2012 Dec 15;131(12):2970-1; author reply 2974-5
[PMID:
22492475
]
Int J Cancer. 2012 Dec 15;131(12):2972-3; author reply 2974-5 [PMID: 22492428 ] |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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