Document Detail

Childhood Behçet's disease: clinical features and comparison with adult-onset disease.
MedLine Citation:
PMID:  10371286     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the clinical spectrum of Behçet's disease (BD) in childhood, in comparison to adult-onset disease. METHODS: Nineteen children, who fulfilled disease criteria up to the age of 16 yr, were studied. The results were compared to those of 34 adult patients with BD. An activity index and severity score were calculated for both study groups. RESULTS: The mean age of disease onset was 6.9+/-3.9 yr, similar ages of onset were found in males and females. The clinical spectrum of childhood BD resembled that of adult disease; however, the prevalence of certain manifestations was different between children and adults. Children with BD had significantly less genital ulcers, less vascular thromboses and more non-specific gastrointestinal symptoms, as well as central nervous system involvement and arthralgia. A relatively high prevalence of uveitis was found in childhood BD. The activity index and severity score were significantly lower in children than in adults. CONCLUSION: Our results point to a similar systemic expression of BD in children and adults; however, the disease seems to run a less severe course in children.
I Krause; Y Uziel; D Guedj; M Mukamel; L Harel; Y Molad; A Weinberger
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Rheumatology (Oxford, England)     Volume:  38     ISSN:  1462-0324     ISO Abbreviation:  Rheumatology (Oxford)     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-06-24     Completed Date:  1999-06-24     Revised Date:  2007-09-06    
Medline Journal Info:
Nlm Unique ID:  100883501     Medline TA:  Rheumatology (Oxford)     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  457-62     Citation Subset:  AIM; IM    
Rheumatology Unit, Rabin Medical Centre, Beilinson Campus, Petah-Tiqva, Israel.
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MeSH Terms
Age Distribution
Age of Onset
Behcet Syndrome / diagnosis*,  epidemiology
Child, Preschool
Severity of Illness Index*

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