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Childhood cardiac outcome after intrauterine laser treatment of twin-twin transfusion syndrome is favourable.
MedLine Citation:
PMID:  25492400     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
AIM: Intrauterine laser treatment is used to alleviate abnormal circulatory load and cardiac morbidity affecting fetuses with twin-twin transfusion syndrome (TTTS). We conducted this childhood follow-up study to fill the gap in knowledge about final cardiac outcomes after such interventions.
METHODS: We investigated 19 TTTS pairs - 11 male and eight female - with a mean age of four-and-a-half years (range 1.1-9.9) using 2D, blood flow and tissue Doppler, 3D and speckle tracking echocardiography, and compared them with 19 age-matched and gender-matched singletons.
RESULTS: The only observed differences in cardiac structure or function between the donors and recipients were related to diastolic ventricular filling. Recipients had a lower left ventricular ratio of early and late diastolic filling compared with their donor co-twins (1.48[0.35] versus 1.66[0.28], p<0.05), but not compared with singleton controls. All observations, except one, were within the reference limits. Speckle tracking could not demonstrate any group differences in systolic ventricular function, besides marginally lower ventricular strain in the donors than controls.
CONCLUSION: Double survivors of laser-treated TTTS showed only minor within-pair differences in diastolic cardiac function at childhood follow-up. Cardiac function in TTTS twins compared well to singleton controls, suggesting a favourable long-term outcome. This article is protected by copyright. All rights reserved.
Authors:
Cecilia Pegelow Halvorsen; Lilly-Ann Mohlkert; Mikael Norman; Sven-Erik Sonesson
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-12-10
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  -     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-10     Completed Date:  -     Revised Date:  2014-12-11    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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