Document Detail

Childhood cardiac function after twin-to-twin transfusion syndrome--a 10-year follow up.
MedLine Citation:
PMID:  19500081     Owner:  NLM     Status:  MEDLINE    
AIM: To perform a 10-year follow up of cardiac structure and function after twin-to-twin transfusion syndrome (TTTS)--a severe foetal circulatory complication associated with myocardial hypertrophy in the recipient twin. METHODS: Cardiac dimensions, systolic and diastolic function as assessed by echocardiography including flow and tissue Doppler velocimetry in 22 healthy survivors of TTTS with a mean age of 9.6 (7.2-11.8) years. RESULTS: The donor and recipient twin did not show any differences in end-diastolic ventricular size, interventricular septum thickness, diameter of right ventricular outflow tract, cardiac valves, coronary arteries or in systolic blood flow velocities. However, compared with the donors, the recipients had significantly lower E/A ratios because of lower E-waves in both mitral (-0.15 +/- 0.10, p < 0.01) and tricuspid (-0.09 +/- 0.07, p < 0.01) valves, indicating reduced early diastolic ventricular fillings compared with donors. CONCLUSION: At school age, twins surviving TTTS had a cardiac structure and function within normal range. There were no differences in heart structure or systolic ventricular function between twins but, compared with the donor twin, we found a reduced early diastolic function in the recipient.
C P Halvorsen; S L Bilock; C Pilo; S-E Sonesson; M Norman
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Twin Study     Date:  2009-06-04
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  98     ISSN:  1651-2227     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-13     Completed Date:  2009-10-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  1468-74     Citation Subset:  IM    
Department of Clinical Science, Södersjukhuset, Karolinska Institute, Stockholm, Sweden.
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MeSH Terms
Blood Flow Velocity
Cohort Studies
Diastole / physiology
Fetofetal Transfusion / complications*
Follow-Up Studies
Hypertrophy / etiology
Myocardium / pathology*
Twins, Monozygotic
Ventricular Dysfunction / etiology*,  ultrasonography
Ventricular Function*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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