Document Detail

Childhood cancer survivorship: an update on evolving paradigms for understanding pathogenesis and screening for therapy-related late effects.
MedLine Citation:
PMID:  23295717     Owner:  NLM     Status:  MEDLINE    
PURPOSE OF REVIEW: Five-year survival for many childhood cancers approaches 80%, and there is a growing number of long-term survivors in the United States. These survivors are at risk for developing adverse health-related complications. We highlight recently published studies that provide new insight into the association between specific therapeutic exposures and late-occurring complications such as second malignant neoplasms, cardiovascular disease, endocrinopathies, and neurocognitive impairment.
RECENT FINDINGS: The incidence for many long-term complications continues to increase with longer follow-up. Investigators have begun to explore the impact of aging and the role of genetic susceptibility as modifiers of risk in diseases wherein there is a clear association between therapeutic exposure and adverse outcome. Increased awareness of the importance of screening has set the stage for assessment of the impact of early detection for reduction of long-term morbidity and mortality among childhood cancer survivors at highest risk for therapy-related complications.
SUMMARY: The long-term health-related burden in childhood cancer survivors is substantial. Recent studies exploring the etiopathogenesis of treatment-related late effects have provided important information that will assist in ongoing efforts to develop personalized cancer care. Efficacious medical interventions are needed to help mitigate treatment-related complications in high-risk survivors.
Saro H Armenian; Leslie L Robison
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in pediatrics     Volume:  25     ISSN:  1531-698X     ISO Abbreviation:  Curr. Opin. Pediatr.     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-08     Completed Date:  2013-06-13     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  9000850     Medline TA:  Curr Opin Pediatr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  16-22     Citation Subset:  IM    
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MeSH Terms
Antineoplastic Agents / adverse effects*
Cardiovascular Diseases / diagnosis,  etiology
Cognition Disorders / diagnosis,  etiology
Endocrine System Diseases / diagnosis,  etiology
Long-Term Care / methods
Mass Screening / methods
Neoplasms / therapy*
Neoplasms, Second Primary / diagnosis
Grant Support
K12 CA001727/CA/NCI NIH HHS; K12 CA001727-14/CA/NCI NIH HHS; P30 CA21765/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS; U10 CA098543/CA/NCI NIH HHS
Reg. No./Substance:
0/Antineoplastic Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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