Document Detail


Childhood adversity and vulnerability to mood and anxiety disorders.
MedLine Citation:
PMID:  9262936     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Based upon epidemiological surveys, adverse childhood events are proposed to be risk factors for adult depressive and anxiety disorders. However, the extent to which these events are seen in clinical patient populations is less clear. We examined the prevalence of a number of proposed risk factors for depression in 650 patients with mood and anxiety disorders at the time of presentation for treatment in an outpatient subspecialty clinic. Emotional abuse, physical abuse, or sexual abuse (childhood adversity) was found in approximately 35% of patients with major depression and panic disorder, was more common in women than men, and was associated with an earlier onset of symptoms. Childhood adversity was also strongly associated with marital discord/divorce, and psychopathology in a parent, suggesting family discord predisposes to childhood abuse. Furthermore, the association of childhood abuse with parental mental illness suggests that genetic and environmental factors are difficult to separate as etiological factors in vulnerability.
Authors:
E A Young; J L Abelson; G C Curtis; R M Nesse
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Depression and anxiety     Volume:  5     ISSN:  1091-4269     ISO Abbreviation:  Depress Anxiety     Publication Date:  1997  
Date Detail:
Created Date:  1997-10-21     Completed Date:  1997-10-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  9708816     Medline TA:  Depress Anxiety     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  66-72     Citation Subset:  IM    
Affiliation:
Department of Psychiatry and Mental Health Research Institute, University of Michigan, Ann Arbor, USA.
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MeSH Terms
Descriptor/Qualifier:
Adult
Age of Onset
Analysis of Variance
Anxiety Disorders / epidemiology*,  etiology,  psychology
Chi-Square Distribution
Child
Child Abuse / psychology*,  statistics & numerical data
Child of Impaired Parents / psychology,  statistics & numerical data
Depressive Disorder / psychology
Disease Susceptibility
Family Health*
Female
Humans
Life Change Events*
Male
Michigan / epidemiology
Mood Disorders / epidemiology*,  etiology,  psychology
Panic Disorder / psychology
Phobic Disorders / psychology
Prevalence
Retrospective Studies
Risk Factors
Severity of Illness Index
Sex Factors
Substance-Related Disorders / complications
Grant Support
ID/Acronym/Agency:
MH 000427/MH/NIMH NIH HHS; MH 50030/MH/NIMH NIH HHS; MH 52724/MH/NIMH NIH HHS

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