| Childhood adversities as predictors of incident coronary heart disease and cerebrovascular disease. | |
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MedLine Citation:
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PMID: 20194205 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Studies suggest that childhood adversities are important determinants of various types of later illnesses as well as poor health behaviour. However, few large-scale prospective studies have examined the associations between childhood adversities and cardiovascular disease. OBJECTIVE: To investigate whether childhood adversities are associated with increased risk of incident cardiovascular disease. DESIGN AND SETTING: Participants were 23 916 men and women in four age groups (20-24, 30-34, 40-44, and 50-54 years) from the Health and Social Support study, a longitudinal study on a random sample representative of the Finnish population. Data from national health registers on coronary heart disease and cerebrovascular disease during a mean follow-up of 6.9 years were linked to survey responses on childhood adversities. Cox proportional hazard models were adjusted for age group and potential mediators (education, health risk behaviours, diabetes and depression). RESULTS: There was a significant linear trend between the number of childhood adversities and disease end points in women. The risk of incident cardiovascular disease was threefold among women exposed concurrently to three types of childhood adversities (financial difficulties, interpersonal conflicts and longstanding illness of a family member). Among men, increased risk was observed only among those with longstanding illness of a family member (HR=1.44; 95% CI 1.06 to 1.96). CONCLUSIONS: In this prospective population-based sample, childhood adversities were associated with a significantly increased risk of objectively verified cardiovascular disease, especially among women but to a lesser extent among men. More studies with prospective settings are needed to confirm the association and possible mechanisms. |
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Authors:
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Jyrki Korkeila; Jussi Vahtera; Katariina Korkeila; Mika Kivim?ki; Markku Sumanen; Karoliina Koskenvuo; Markku Koskenvuo |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Heart (British Cardiac Society) Volume: 96 ISSN: 1468-201X ISO Abbreviation: Heart Publication Date: 2010 Feb |
Date Detail:
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Created Date: 2010-03-02 Completed Date: 2010-04-09 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9602087 Medline TA: Heart Country: England |
Other Details:
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Languages: eng Pagination: 298-303 Citation Subset: AIM; IM |
Affiliation:
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Department of Psychiatry, University of Turku, Kunnallissairaalantie 20, 20700 Turku, Finland. jyrki.korkeila@utu.fi |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Age Distribution Cerebrovascular Disorders / epidemiology, psychology* Child Coronary Disease / epidemiology, psychology* Female Finland / epidemiology Humans Incidence Life Change Events* Male Middle Aged Proportional Hazards Models Risk Factors Young Adult |
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