Document Detail


Childhood and adolescent tuberculosis in northern Taiwan: an institutional experience during 1994-1999.
MedLine Citation:
PMID:  11529547     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
This study evaluated the clinical characteristics of childhood and adolescent tuberculosis (TB) at the end of the twentieth century in a referral children's hospital in northern Taiwan. The hospital charts were reviewed retrospectively of children/adolescents aged less than 18 y who were seen in a children's hospital in northern Taiwan between 1994 and 1999 and diagnosed with TB. A total of 62 individuals was diagnosed during this period. The patients' demographic data, presenting symptoms, clinical features, bacteriological results, drug susceptibility and tuberculin skin-test results were analysed. Most diagnosed cases lay in one of two main age ranges, younger than 5 y and adolescents. The presenting symptoms of study subjects were typically non-specific. Bone involvement occurred for 21 patients (33.9%) and was the most common extrapulmonary manifestation. Mycobacterium tuberculosis was isolated from 47 patients (75.8%). Five isolates were resistant to pyrazinamide, three to streptomycin and one to isoniazid, but no multidrug resistant isolates of TB were detected from culture-proven cases. Seventeen of 47 (36.2%) culture-proven patients revealed negative acid-fast staining initially but, subsequently, M. tuberculosis was isolated from various clinical specimens using a standard method at a later date. The tuberculin skin test was positive for 24 of 32 patients (75%) who received such an examination. Conclusion: Extrathoracic TB was more common in children below 5 y of age than their adolescent counterparts, and chiefly involved the peripheral long bones. The potential drug resistance of M. tuberculosis in childhood and adolescent TB did not appear to have been a major problem in northern Taiwan before the year 2000.
Authors:
K S Wong; C H Chiu; Y C Huang; T Y Lin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta paediatrica (Oslo, Norway : 1992)     Volume:  90     ISSN:  0803-5253     ISO Abbreviation:  Acta Paediatr.     Publication Date:  2001 Aug 
Date Detail:
Created Date:  2001-08-31     Completed Date:  2002-01-03     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9205968     Medline TA:  Acta Paediatr     Country:  Norway    
Other Details:
Languages:  eng     Pagination:  943-7     Citation Subset:  IM    
Affiliation:
Division of Pediatric Pulmonology, Chang Gung Children's Hospital, Taoyuan, Taiwan, ROC. pchest@adm.cgmh.org.tw
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Biopsy / methods
Child
Child, Preschool
Female
Humans
Infant
Male
Mycobacterium tuberculosis / isolation & purification
Retrospective Studies
Skin Tests / methods
Taiwan / epidemiology
Tuberculosis, Multidrug-Resistant / diagnosis*,  epidemiology,  microbiology
Tuberculosis, Osteoarticular / diagnosis,  epidemiology*,  microbiology
Tuberculosis, Pulmonary / diagnosis,  epidemiology*,  microbiology

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