| Childhood acute lymphoblastic leukemia with natural killer activity. Clinical and cellular features of three cases. | |
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MedLine Citation:
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PMID: 6332668 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Leukemic cells from 3 of 28 children with acute lymphoblastic leukemia (ALL) had natural killer (NK) activity against K562 and Molt-3, but not against Raji as determined by the 4-hour 51Cr release assay at a 40:1 effector:target ratio; the highest percent lysis against K562 in each patient ranged from 55.9% to 147.4% of the normal lymphocyte value and that against Molt-3 from 28.0% to 127.9%. Their leukemic cells were nonphagocytic, nonadherent, and negative for nonspecific esterase. Leukemic cells from two of them displayed similar morphologic and immunologic features. The cells had a round nucleus, and were E-receptors (E)+, Leu-5+, IgG-Fc+, Ia+, OKM1+ or OKM1-, T-cell antigens-, B markers-, and monocyte antigen-, indicating their NK cell origin. The other patient's cells were characterized by the irregularly shaped nucleus, and were E+, Leu-5+, IgG-Fc+, T+, OKT6+, Leu-2a+, and OKM1+. The presence of E which are identical to E of T-cells and a high density of T-cell antigens including OKT6 on the cells suggested their T-cell nature. Of the three patients, two without thymic enlargement had leukemic cells of NK cell origin, and the other one with the symptom leukemic cells of the T-cell lineage, the clinical feature probably reflecting the cell lineage of their leukemic cells. |
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Authors:
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A Komiyama; S Yamada; H Kawai; Y Miyagawa; T Akabane |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer Volume: 54 ISSN: 0008-543X ISO Abbreviation: Cancer Publication Date: 1984 Oct |
Date Detail:
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Created Date: 1984-11-01 Completed Date: 1984-11-01 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0374236 Medline TA: Cancer Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1547-53 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Cell Adhesion Child Child, Preschool Cytotoxicity, Immunologic Female Histocompatibility Antigens / analysis Humans Infant Killer Cells, Natural / immunology*, pathology Leukemia, Lymphoid / immunology*, pathology Male Phagocytosis T-Lymphocytes / immunology |
| Chemical | |
Reg. No./Substance:
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0/Histocompatibility Antigens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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