| Childhood acute bacterial meningitis: risk factors for acute neurological complications and neurological sequelae. | |
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MedLine Citation:
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PMID: 22170227 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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OBJECTIVE: To assess acute neurological complications and neurological sequelae of childhood acute bacterial meningitis in order to determine possible warning signs. METHODS: This retrospective study evaluated children with acute bacterial meningitis (between 1 month and 14 years of age) admitted between 2003 and 2006. RESULTS: Of the 44 patients studied, 17 (38.6%) had acute neurological complications. Seizure was the most frequent (31.8%) complication. Patients with acute neurological complications showed a higher frequency of lower neutrophil count (p = 0.03), seizure at admission (p < 0.01), and S. pneumoniae as the etiologic agent (p = 0.01). Risk factors for the development of acute neurological complications were S. pneumoniae (odds ratio [OR] = 6.4, confidence interval [CI] 1.7-24.7) and neutrophil count < 60% (p < 0.01). Of the 35 patients who were followed up, 14 had neurological sequelae (40%). Behavioral change (22.9%) was the most frequent sequela. Seizures at admission (OR = 5.6, CI 1.2-25.9), cerebrospinal fluid protein concentration > 200 mg/dL (p < 0.01), and cerebrospinal fluid glucose concentration/glycemia ratio (p < 0.01) were identified as risk variables for sequelae. CONCLUSION: Neutrophil count < 60%, seizure at admission, and S. pneumoniae as the etiologic agent were identified as warning signs for acute neurological complications, while protein levels, cerebrospinal fluid glucose concentration/glycemia ratio, and seizure at admission were seen as risk factors for neurological sequelae. |
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Authors:
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Sérgio A Antoniuk; Fátima Hamdar; Renata D Ducci; Ariane T F Kira; Mônica N L Cat; Cristina R da Cruz |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Jornal de pediatria Volume: 87 ISSN: 1678-4782 ISO Abbreviation: J Pediatr (Rio J) Publication Date: 2011 Nov |
Date Detail:
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Created Date: 2011-12-15 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 2985188R Medline TA: J Pediatr (Rio J) Country: Brazil |
Other Details:
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Languages: eng Pagination: 535-40 Citation Subset: IM |
Affiliation:
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Universidade Federal do Paraná (UFPR), Curitiba, PR, Brazil. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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