Document Detail


Childhood obesity and asthma control in the GALA II and SAGE II studies.
MedLine Citation:
PMID:  23392439     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
RATIONALE: Obesity is associated with increased asthma morbidity, lower drug responsiveness to inhaled corticosteroids, and worse asthma control. However, most prior investigations on obesity and asthma control have not focused on pediatric populations, considered environmental exposures, or included minority children.
OBJECTIVES: To examine the association between body mass index categories and asthma control among boys and girls; and whether these associations are modified by age and race/ethnicity.
METHODS: Children and adolescents ages 8-19 years (n = 2,174) with asthma were recruited from the Genes-environments and Admixture in Latino Americans (GALA II) Study and the Study of African Americans, Asthma, Genes, and Environments (SAGE II). Ordinal logistic regression was used to estimate odds ratios (OR) and their confidence intervals (95% CI) for worse asthma control.
MEASUREMENTS AND MAIN RESULTS: In adjusted analyses, boys who were obese had a 33% greater chance of having worse asthma control than their normal-weight counterparts (OR, 1.33; 95% CI, 1.04-1.71). However, for girls this association varied with race and ethnicity (P interaction = 0.008). When compared with their normal-weight counterparts, obese African American girls (OR, 0.65; 95% CI, 0.41-1.05) were more likely to have better controlled asthma, whereas Mexican American girls had a 1.91 (95% CI, 1.12-3.28) greater odds of worse asthma control.
CONCLUSIONS: Worse asthma control is uniformly associated with increased body mass index in boys. Among girls, the direction of this association varied with race/ethnicity.
Authors:
Luisa N Borrell; Elizabeth A Nguyen; Lindsey A Roth; Sam S Oh; Haig Tcheurekdjian; Saunak Sen; Adam Davis; Harold J Farber; Pedro C Avila; Emerita Brigino-Buenaventura; Michael A Lenoir; Fred Lurmann; Kelley Meade; Denise Serebrisky; William Rodriguez-Cintron; Rajesh Kumar; Jose R Rodriguez-Santana; Shannon M Thyne; Esteban G Burchard
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  American journal of respiratory and critical care medicine     Volume:  187     ISSN:  1535-4970     ISO Abbreviation:  Am. J. Respir. Crit. Care Med.     Publication Date:  2013 Apr 
Date Detail:
Created Date:  2013-04-01     Completed Date:  2013-05-21     Revised Date:  2014-04-01    
Medline Journal Info:
Nlm Unique ID:  9421642     Medline TA:  Am J Respir Crit Care Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  697-702     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adolescent
African Americans
Age Factors
Asthma / complications*,  ethnology
Body Mass Index
Child
Disease Progression
Female
Hispanic Americans
Humans
Logistic Models
Male
Obesity / complications*,  ethnology
Risk Factors
Severity of Illness Index
Sex Factors
Tobacco Smoke Pollution / adverse effects,  statistics & numerical data
Grant Support
ID/Acronym/Agency:
ES015794/ES/NIEHS NIH HHS; K23-HL093023/HL/NHLBI NIH HHS; M01-RR00188/RR/NCRR NIH HHS; P60 MD006902/MD/NIMHD NIH HHS; P60MD006902/MD/NIMHD NIH HHS; R01-HL004464/HL/NHLBI NIH HHS; R01-HL078885/HL/NHLBI NIH HHS; R01-HL088133/HL/NHLBI NIH HHS; R01-HL104608/HL/NHLBI NIH HHS; R25-CA113710/CA/NCI NIH HHS; T32-GM007546/GM/NIGMS NIH HHS; U19-AI077439/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Tobacco Smoke Pollution
Comments/Corrections
Comment In:
Am J Respir Crit Care Med. 2013 Apr 1;187(7):667-8   [PMID:  23540871 ]
Erratum In:
Am J Respir Crit Care Med. 2013 Nov 1;88(9):1173

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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