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Childhood chronic myeloid leukemia with monocytosis.
MedLine Citation:
PMID:  20882436     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
We report two cases of chronic myeloid leukemia (CML) in childhood presenting with monocytosis. History, physical examination and laboratory findings were in favor of juvenile myelomonocytic leukemia in both the cases, but reverse transcriptase polymerase chain reaction (RT-PCR) detected b2a2 and b3a2 transcript of p210 bcr-abl protein characteristic of major BCR breakpoint. Presence of monocytosis in early childhood suggests a viral infection or JMML but a possibility of CML with monocytosis needs to be considered.
Authors:
Nidhi Gupta; Ritu Gupta; Surender Kumar Sharawat; Sameer Bakhshi
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Publication Detail:
Type:  Journal Article     Date:  2010-09-30
Journal Detail:
Title:  Indian journal of pediatrics     Volume:  77     ISSN:  0973-7693     ISO Abbreviation:  Indian J Pediatr     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-10-27     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0417442     Medline TA:  Indian J Pediatr     Country:  India    
Other Details:
Languages:  eng     Pagination:  1143-5     Citation Subset:  IM    
Affiliation:
Laboratory Oncology Unit, Dr. B.R. Ambedkar Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, New Delhi, 110029, India.
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