| Child versus adult research: the gap in high-quality study design. | |
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MedLine Citation:
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PMID: 18595986 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: The objective of this study was to determine whether there were differences in study design and purpose between published child- and adult-focused clinical research. METHODS: We reviewed all articles published in the New England Journal of Medicine, Journal of the American Medical Association, Annals of Internal Medicine, Pediatrics, Archives of Internal Medicine, and Archives of Adolescent and Pediatric Medicine during the first 3 months of 2005 and assessed each study's design and purpose. We compared articles focused on adults with those focused on children. RESULTS: We included 370 original research reports in our analysis (New England Journal of Medicine, n = 46; Journal of the American Medical Association, n = 60; Annals of Internal Medicine, n = 27; Pediatrics, n = 130; Archives of Internal Medicine, n = 73; Archives of Adolescent and Pediatric Medicine, n = 34), of which 189 included only adults as subjects and 181 only children. Among adult studies, compared with child studies, there were more randomized, controlled trials (23.8% vs 8.8%) and systematic reviews (10.6% vs 1.7%) and fewer cross sectional studies (16.9% vs 40.9%). Study purposes also varied, with studies of therapies constituting 38.1% of adult studies, compared with 17.7% of child studies. In contrast, epidemiological studies, defined as studies describing the prevalence or incidence of diseases or risk factors or showing associations between risk factors and diseases, constituted 6.4% of adult studies, compared with 26.5% of child studies. CONCLUSIONS: In 6 leading generalist and specialist journals, studies involving adults were significantly more likely than child studies to be randomized, controlled trials, systematic reviews, or studies of therapies. If such studies are to be viewed as the highest possible quality of evidence, then this difference has implications for quality of care for children and for funding and future directions in clinical research involving children. |
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Authors:
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Carolina Martinez-Castaldi; Michael Silverstein; Howard Bauchner |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Pediatrics Volume: 122 ISSN: 1098-4275 ISO Abbreviation: Pediatrics Publication Date: 2008 Jul |
Date Detail:
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Created Date: 2008-07-03 Completed Date: 2008-07-31 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376422 Medline TA: Pediatrics Country: United States |
Other Details:
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Languages: eng Pagination: 52-7 Citation Subset: AIM; IM |
Affiliation:
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Division of General Pediatrics, Boston University School of Medicine, Boston Medical Center, 88 E Newton St, Vose 3, Boston, MA 02118, USA. carolina.martinez-castaldi@bmc.org |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Child Humans Periodicals as Topic / statistics & numerical data Randomized Controlled Trials as Topic Research Design / statistics & numerical data* |
| Grant Support | |
ID/Acronym/Agency:
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T32 HP1001414//PHS HHS |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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