Document Detail


Child neurodevelopmental outcome and maternal occupational exposure to solvents.
MedLine Citation:
PMID:  15466682     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Many women of reproductive age are employed in industries involving exposure to organic solvents. Animal toxicological studies and human case reports demonstrate that high exposure to solvents causes neurodevelopmental toxicity in exposed offspring. Data from occupationally exposed women and their children are few. OBJECTIVE: To compare the cognitive, language, and motor performance and the behavioral achievements of children whose mothers were exposed occupationally to organic solvents during pregnancy with those of a matched unexposed control group. PARTICIPANTS: Thirty-two pregnant women occupationally exposed to organic solvents were recruited during pregnancy and followed up. Their offspring (age range, 3-9 years) were tested for cognitive functioning (IQ), language, visual-motor functioning, and behavioral functioning and were compared with a matched unexposed control group that was recruited and tested in a similar manner. Examiners were blinded to the exposure status. RESULTS: Mothers occupationally exposed to organic solvents did not differ significantly from matched controls in demographic variables. After controlling for potential confounding because of maternal IQ and maternal education, children exposed in utero to organic solvents obtained lower scores on subtests of intellectual, language, motor, and neurobehavioral functioning. CONCLUSIONS: In utero exposure to organic solvents is associated with poorer performance on some specific subtle measures of neurocognitive function, language, and behavior. Reducing exposure in pregnancy is merited until more refined risk assessment is possible. Further studies that address exposure to specific solvents, dose, and gestational timing of exposure are needed.
Authors:
Dionne Laslo-Baker; Maru Barrera; Dafna Knittel-Keren; Eran Kozer; Jacob Wolpin; Sohail Khattak; Richard Hackman; Joanne Rovet; Gideon Koren
Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Archives of pediatrics & adolescent medicine     Volume:  158     ISSN:  1072-4710     ISO Abbreviation:  Arch Pediatr Adolesc Med     Publication Date:  2004 Oct 
Date Detail:
Created Date:  2004-10-06     Completed Date:  2004-11-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9422751     Medline TA:  Arch Pediatr Adolesc Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  956-61     Citation Subset:  AIM; IM    
Affiliation:
Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada.
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MeSH Terms
Descriptor/Qualifier:
Case-Control Studies
Child
Child Development / physiology
Child, Preschool
Developmental Disabilities / chemically induced*,  diagnosis*,  epidemiology
Female
Follow-Up Studies
Humans
Incidence
Linear Models
Male
Maternal Exposure*
Multivariate Analysis
Neuropsychological Tests
Occupational Exposure*
Pregnancy
Prenatal Exposure Delayed Effects*
Prognosis
Psychomotor Performance
Reference Values
Risk Assessment
Solvents / toxicity*
Chemical
Reg. No./Substance:
0/Solvents
Comments/Corrections
Comment In:
Arch Pediatr Adolesc Med. 2005 Jul;159(7):690; author reply 690-1   [PMID:  15997007 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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