| Child neurodevelopmental outcome and maternal occupational exposure to solvents. | |
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MedLine Citation:
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PMID: 15466682 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Many women of reproductive age are employed in industries involving exposure to organic solvents. Animal toxicological studies and human case reports demonstrate that high exposure to solvents causes neurodevelopmental toxicity in exposed offspring. Data from occupationally exposed women and their children are few. OBJECTIVE: To compare the cognitive, language, and motor performance and the behavioral achievements of children whose mothers were exposed occupationally to organic solvents during pregnancy with those of a matched unexposed control group. PARTICIPANTS: Thirty-two pregnant women occupationally exposed to organic solvents were recruited during pregnancy and followed up. Their offspring (age range, 3-9 years) were tested for cognitive functioning (IQ), language, visual-motor functioning, and behavioral functioning and were compared with a matched unexposed control group that was recruited and tested in a similar manner. Examiners were blinded to the exposure status. RESULTS: Mothers occupationally exposed to organic solvents did not differ significantly from matched controls in demographic variables. After controlling for potential confounding because of maternal IQ and maternal education, children exposed in utero to organic solvents obtained lower scores on subtests of intellectual, language, motor, and neurobehavioral functioning. CONCLUSIONS: In utero exposure to organic solvents is associated with poorer performance on some specific subtle measures of neurocognitive function, language, and behavior. Reducing exposure in pregnancy is merited until more refined risk assessment is possible. Further studies that address exposure to specific solvents, dose, and gestational timing of exposure are needed. |
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Authors:
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Dionne Laslo-Baker; Maru Barrera; Dafna Knittel-Keren; Eran Kozer; Jacob Wolpin; Sohail Khattak; Richard Hackman; Joanne Rovet; Gideon Koren |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Archives of pediatrics & adolescent medicine Volume: 158 ISSN: 1072-4710 ISO Abbreviation: Arch Pediatr Adolesc Med Publication Date: 2004 Oct |
Date Detail:
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Created Date: 2004-10-06 Completed Date: 2004-11-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9422751 Medline TA: Arch Pediatr Adolesc Med Country: United States |
Other Details:
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Languages: eng Pagination: 956-61 Citation Subset: AIM; IM |
Affiliation:
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Motherisk Program and Division of Clinical Pharmacology and Toxicology, The Hospital for Sick Children, Toronto, Ontario, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Case-Control Studies Child Child Development / physiology Child, Preschool Developmental Disabilities / chemically induced*, diagnosis*, epidemiology Female Follow-Up Studies Humans Incidence Linear Models Male Maternal Exposure* Multivariate Analysis Neuropsychological Tests Occupational Exposure* Pregnancy Prenatal Exposure Delayed Effects* Prognosis Psychomotor Performance Reference Values Risk Assessment Solvents / toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Solvents |
| Comments/Corrections | |
Comment In:
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Arch Pediatr Adolesc Med. 2005 Jul;159(7):690; author reply 690-1
[PMID:
15997007
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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