Document Detail


Child abuse and epigenetic mechanisms of disease risk.
MedLine Citation:
PMID:  23332324     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: Child abuse is highly prevalent and associated with increased risk for a range of health problems, including cancer, cardiovascular disease, diabetes, psychiatric disorders, and other health problems. Little is currently known about the mechanism by which early adversity confers risk for health problems later in life.
PURPOSE: To determine if there are epigenetic differences associated with child maltreatment that may help explain association between adverse childhood experiences and later health problems.
METHODS: As part of a study examining genetic and environmental factors associated with depression, saliva DNA specimens were collected on 96 maltreated children removed from their parents due to abuse or neglect and 96 demographically matched control children between 2003 and 2010. In 2011, the Illumina 450K BeadChip was used on stored DNA specimens and analyzed to examine whole-genome methylation differences between maltreated and control children.
RESULTS: After controlling for multiple comparisons, maltreated and control children had significantly different methylation values at 2868 CpG sites (p<5.0 × 10(-7), all sites; average methylation difference per site=17%; range=1%-62%). The gene set contained numerous markers of diseases and biological processes related to the health problems associated with early childhood adversity.
CONCLUSIONS: Although replication is required, this study suggests that epigenetic mechanisms may be associated with risk for health problems later in life in maltreated children. This study lays the groundwork for future studies examining health and methylation measures to further characterize the role of epigenetic mechanisms in conferring risk for medical problems in individuals with histories of early adversity.
Authors:
Bao-Zhu Yang; Huiping Zhang; Wenjing Ge; Natalie Weder; Heather Douglas-Palumberi; Francheska Perepletchikova; Joel Gelernter; Joan Kaufman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  American journal of preventive medicine     Volume:  44     ISSN:  1873-2607     ISO Abbreviation:  Am J Prev Med     Publication Date:  2013 Feb 
Date Detail:
Created Date:  2013-01-21     Completed Date:  2013-06-27     Revised Date:  2014-02-04    
Medline Journal Info:
Nlm Unique ID:  8704773     Medline TA:  Am J Prev Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  101-7     Citation Subset:  IM    
Copyright Information:
Copyright © 2013 American Journal of Preventive Medicine. Published by Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Case-Control Studies
Child
Child Abuse*
Child, Preschool
DNA / analysis
DNA Methylation*
Epigenesis, Genetic*
Female
Genome-Wide Association Study
Humans
Male
Oligonucleotide Array Sequence Analysis
Risk Factors
Saliva
Grant Support
ID/Acronym/Agency:
AA017535/AA/NIAAA NIH HHS; AA11330R01/AA/NIAAA NIH HHS; DA12690/DA/NIDA NIH HHS; DA12849/DA/NIDA NIH HHS; K01 DA24758/DA/NIDA NIH HHS; K99/R00 DA022891/DA/NIDA NIH HHS; MH077087/MH/NIMH NIH HHS; R01 AA017535/AA/NIAAA NIH HHS; R01 MH077087/MH/NIMH NIH HHS; R01 MH098073/MH/NIMH NIH HHS; T32 MH067763/MH/NIMH NIH HHS
Chemical
Reg. No./Substance:
9007-49-2/DNA
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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