Document Detail

Child neurology: diagnosis of Lambert-Eaton myasthenic syndrome in children.
MedLine Citation:
PMID:  23690300     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To report a case of Lambert-Eaton myasthenic syndrome (LEMS) in a child and review the existing literature of LEMS in children.
METHODS: We report a pediatric case of LEMS with the classic clinical triad of proximal weakness, autonomic dysfunction, and areflexia; the characteristic increment in compound motor action potential on high-frequency repetitive nerve stimulation; and positive serum P/Q-type voltage-gated calcium channel antibodies. Only 11 pediatric cases of LEMS have been reported in the literature.
RESULTS: The patient's presentation with LEMS led to the diagnosis of occult neuroblastoma. Based on review of the existing pediatric literature, no consistent clinical or electrodiagnostic criteria exist to diagnose LEMS in children.
CONCLUSIONS: There exists a need for consistent clinical criteria and electrodiagnostic testing for prompt diagnosis of LEMS in children. Prompt identification of LEMS will alert the physician to search for malignancy or another immune-mediated process.
Bethanie Morgan-Followell; Emily de Los Reyes
Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Neurology     Volume:  80     ISSN:  1526-632X     ISO Abbreviation:  Neurology     Publication Date:  2013 May 
Date Detail:
Created Date:  2013-05-21     Completed Date:  2013-07-16     Revised Date:  2013-08-27    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  e220-2     Citation Subset:  AIM; IM    
Division of Child Neurology, Nationwide Children's Hospital, The Ohio State University, Columbus, USA.
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MeSH Terms
Child, Preschool
Electromyography / methods
Lambert-Eaton Myasthenic Syndrome / diagnosis*,  physiopathology*
Neural Conduction / physiology

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