Document Detail


Child Development and Structural Variation in the Human Genome.
MedLine Citation:
PMID:  23311762     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Structural variation of the human genome sequence is the insertion, deletion, or rearrangement of stretches of DNA sequence sized from around 1,000 to millions of base pairs. Over the past few years, structural variation has been shown to be far more common in human genomes than previously thought. Very little is currently known about the effects of structural variation on normal child development, but such effects could be of considerable significance. This review provides an overview of the phenomenon of structural variation in the human genome sequence, describing the novel genomics technologies that are revolutionizing the way structural variation is studied and giving examples of genomic structural variations that affect child development.
Authors:
Ying Zhang; Rajini Haraksingh; Fabian Grubert; Alexej Abyzov; Mark Gerstein; Sherman Weissman; Alexander E Urban
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-1-13
Journal Detail:
Title:  Child development     Volume:  -     ISSN:  1467-8624     ISO Abbreviation:  Child Dev     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-1-14     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372725     Medline TA:  Child Dev     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2013 The Authors. Child Development © 2013 Society for Research in Child Development, Inc.
Affiliation:
Yale University.
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