Document Detail


Chilblain-like leukemia cutis.
MedLine Citation:
PMID:  17300647     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We present a 6-year-old girl with an 8-month history of fluctuating chilblain-like lesions on the toes. A full blood count showed slight thrombocytopenia and monocytosis. A skin biopsy specimen showed a dense perivascular and superficial dermal cellular infiltrate which was CD3(-), CD43(+), and lysosyme + on immunocytochemistry, suggesting a monocytic origin. Juvenile myelomonocytic leukemia was diagnosed after a bone marrow biopsy and spontaneous marrow colony growth in culture.
Authors:
Andrew G Affleck; Jane C Ravenscroft; Iain H Leach
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pediatric dermatology     Volume:  24     ISSN:  0736-8046     ISO Abbreviation:  Pediatr Dermatol     Publication Date:    2007 Jan-Feb
Date Detail:
Created Date:  2007-02-15     Completed Date:  2007-05-15     Revised Date:  2009-03-03    
Medline Journal Info:
Nlm Unique ID:  8406799     Medline TA:  Pediatr Dermatol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  38-41     Citation Subset:  IM    
Affiliation:
Department of Dermatology, Queen's Medical Centre, University Hospital Nottingham NHS Trust, Nottingham, UK. andyaffleck@doctors.org.uk
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MeSH Terms
Descriptor/Qualifier:
Biopsy
Chilblains
Child
Female
Humans
Leukemia / diagnosis*,  pathology
Leukemia, Myelomonocytic, Chronic / diagnosis,  pathology*
Skin Neoplasms / diagnosis*,  pathology
Toes

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