Document Detail

Chief cell mass after short-term ranitidine treatment for duodenal ulcer.
MedLine Citation:
PMID:  1427584     Owner:  NLM     Status:  MEDLINE    
The chief cell mass and the parietal cell mass were evaluated in endoscopically obtained biopsy specimens of fundic mucosa from 15 duodenal ulcer patients before and after ranitidine treatment. Patients were given ranitidine, 300 mg/day, for 8 weeks. Chief cell mass and parietal cell mass were expressed respectively by a "zymogenous index" (ZI) and a "parietal index" (PI), obtained by multiplying the number of cells per mm2 by the thickness of the glandular layer. From the results of this study it would appear that, in patients with duodenal ulcer, treatment with ranitidine at a dose of 300 mg/day for 8 weeks results in a significant increase in parietal cell mass and a decrease in chief cess mass.
G Testino
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hepato-gastroenterology     Volume:  39     ISSN:  0172-6390     ISO Abbreviation:  Hepatogastroenterology     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-12-23     Completed Date:  1992-12-23     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8007849     Medline TA:  Hepatogastroenterology     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  358-61     Citation Subset:  IM    
Department of Gastroenterology, San Martino Hospital, Genova, Italy.
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MeSH Terms
Cell Division / drug effects
Duodenal Ulcer / drug therapy*,  pathology*
Fermentation / drug effects
Intestinal Mucosa / drug effects,  pathology*
Middle Aged
Parietal Cells, Gastric / drug effects,  pathology*
Ranitidine / therapeutic use*
Time Factors
Reg. No./Substance:

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