| Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage. | |
| | |
MedLine Citation:
|
PMID: 20170381 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease. |
| | |
Authors:
|
Youzuo Zhang; Tomomi Kouguchi; Muneshige Shimizu; Takashi Ohmori; Yoshihisa Takahata; Fumiki Morimatsu |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
|
Title: Journal of medicinal food Volume: 13 ISSN: 1557-7600 ISO Abbreviation: J Med Food Publication Date: 2010 Apr |
Date Detail:
|
Created Date: 2010-04-23 Completed Date: 2010-10-21 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9812512 Medline TA: J Med Food Country: United States |
Other Details:
|
Languages: eng Pagination: 399-405 Citation Subset: IM |
Affiliation:
|
R&D Center, Nippon Meat Packers Inc., Tsukuba, Ibaraki, Japan. y.zhang@nipponham.co.jp |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Angiotensin-Converting Enzyme Inhibitors
/
pharmacology,
therapeutic use* Animals Antihypertensive Agents / pharmacology, therapeutic use* Aorta / drug effects Blood Pressure / drug effects* Chickens Collagen / pharmacology, therapeutic use* Endothelial Cells / drug effects Endothelium, Vascular / drug effects*, physiopathology Hydrolysis Hypertension / physiopathology, prevention & control* Intercellular Adhesion Molecule-1 / blood Male Nitric Oxide / blood Rats Rats, Inbred WKY Vascular Diseases / prevention & control Vasodilation / drug effects* |
| Chemical | |
Reg. No./Substance:
|
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 10102-43-9/Nitric Oxide; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Essential Oil Terpenes: Adjunctive Role in the Management of Childhood Urolithiasis.
Next Document: Cytotoxic and Cell Cycle Effects Induced by Two Herbal Extracts on Human Cervix Carcinoma and Human ...