Document Detail

Chicken collagen hydrolysate protects rats from hypertension and cardiovascular damage.
MedLine Citation:
PMID:  20170381     Owner:  NLM     Status:  MEDLINE    
We previously reported that chicken collagen hydrolysate (CCH) has strong angiotensin I converting enzyme (ACE) inhibitory activity and antihypertensive effects on spontaneously hypertensive rats. Here, we investigated the chronic therapy effects of CCH on blood pressure and vascular relaxation in a cardiovascular damage model of Wistar-Kyoto rats induced by N-nitro-l-arginine methyl ester (L-NAME). Following co-treatment with CCH for 4 weeks, the increment of systolic blood pressure was suppressed significantly. At 8 weeks, the vasorelaxation of thoracic aorta increased significantly, and cardiovascular damage was ameliorated. The concentration of soluble intercellular adhesion molecule-1 (ICAM-1) in blood was reduced significantly by long-term administration of CCH, whereas the nitric oxide concentration was increased significantly at 1 hour post-treatment. The results suggest that beneficial effects of CCH result from antihypertensive function, but also from inhibition of cardiovascular damage to the endothelial cells via its ACE inhibitory activity and regulation of nitric oxide and ICAM-1, which suggests that CCH may be useful as a medicinal food for patients with cardiovascular disease.
Youzuo Zhang; Tomomi Kouguchi; Muneshige Shimizu; Takashi Ohmori; Yoshihisa Takahata; Fumiki Morimatsu
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of medicinal food     Volume:  13     ISSN:  1557-7600     ISO Abbreviation:  J Med Food     Publication Date:  2010 Apr 
Date Detail:
Created Date:  2010-04-23     Completed Date:  2010-10-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9812512     Medline TA:  J Med Food     Country:  United States    
Other Details:
Languages:  eng     Pagination:  399-405     Citation Subset:  IM    
R&D Center, Nippon Meat Packers Inc., Tsukuba, Ibaraki, Japan.
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MeSH Terms
Angiotensin-Converting Enzyme Inhibitors / pharmacology,  therapeutic use*
Antihypertensive Agents / pharmacology,  therapeutic use*
Aorta / drug effects
Blood Pressure / drug effects*
Collagen / pharmacology,  therapeutic use*
Endothelial Cells / drug effects
Endothelium, Vascular / drug effects*,  physiopathology
Hypertension / physiopathology,  prevention & control*
Intercellular Adhesion Molecule-1 / blood
Nitric Oxide / blood
Rats, Inbred WKY
Vascular Diseases / prevention & control
Vasodilation / drug effects*
Reg. No./Substance:
0/Angiotensin-Converting Enzyme Inhibitors; 0/Antihypertensive Agents; 10102-43-9/Nitric Oxide; 126547-89-5/Intercellular Adhesion Molecule-1; 9007-34-5/Collagen

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