Document Detail


Chick wing innervation. I. Time course of innervation and early differentiation of the peripheral nerve pattern.
MedLine Citation:
PMID:  7665727     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anterograde transport of horseradish peroxidase was used to map the initial projection patterns of motor and sensory axons innervating the wing of the chick embryo. Injections which resulted in labeling large numbers of motor and sensory axons, separately or in combination, were used to define the time course of innervation and to visualize the progressive morphogenesis of the peripheral nerve pattern. Motor axons emerged from the spinal cord and accumulated near the ventromedial border of the myotome where they remained for up to 16 hours before growing into the plexus region and limb bud. Despite the known later time of sensory neuron production, the first sensory axons projected to the wing at the same time as motor axons. When axons first entered the wing bud, they were distributed in two loosely organized sheets of axon fascicles, one projecting to dorsal muscle mass, the other to ventral muscle mass. The width of the sheets was between one-third to one-half the width of the wing bud, and this distance was more than twice the diameter of the proximal nerve trunks measured at stage 28. In the proximal limb the basic pattern of peripheral nerves emerged gradually from stages 26 to 28. During these stages, the loosely organized sheets of axonal fascicles seen at younger stages were progressively transformed into several coherent nerve trunks and muscle nerves extended from common nerve trunks. The implication of these observations is that many outgrowing axons appear not to follow preformed pathways corresponding to the mature peripheral nerve branching pattern. This pattern may instead result from axonal recognition of cues within a largely undifferentiated limb bud, and from the subsequent bundling together of loosely organized axon fascicles. These events occur concurrently with limb growth and differentiation.
Authors:
M Hollyday
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The Journal of comparative neurology     Volume:  357     ISSN:  0021-9967     ISO Abbreviation:  J. Comp. Neurol.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-10-10     Completed Date:  1995-10-10     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0406041     Medline TA:  J Comp Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  242-53     Citation Subset:  IM    
Affiliation:
Department of Biology, Bryn Mawr College, Pennsylvania 19010, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Axons / physiology,  ultrastructure
Brachial Plexus / growth & development,  ultrastructure
Cell Differentiation
Chick Embryo
Histocytochemistry
Horseradish Peroxidase
Mitosis / physiology
Motor Neurons / physiology,  ultrastructure
Neurons, Afferent / physiology,  ultrastructure
Peripheral Nerves / cytology,  embryology*,  ultrastructure
Wing / embryology*,  innervation*
Grant Support
ID/Acronym/Agency:
NS-14066/NS/NINDS NIH HHS; NS-25340/NS/NINDS NIH HHS
Chemical
Reg. No./Substance:
EC 1.11.1.-/Horseradish Peroxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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