Document Detail

Cheyne-Stokes respiration in heart failure: cycle length is dependent on left ventricular ejection fraction.
MedLine Citation:
PMID:  20064744     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Cheyne-Stokes respiration (CSR) is common in patients with congestive heart failure (CHF) and is associated with poor prognosis. The aim of this study was to analyse the characteristics of CSR in patients with varying degrees of impaired left ventricular ejection fraction (LVEF). METHODS: A total of 104 patients with CSR (apnea-hypopnea index [AHI]15/h) and exertional dyspnea were divided into FIVE groups according to their LVEF (<20% upto 50%). A subgroup of 22 patients was studied twice: 15 in whom LVEF improved between studies and 7 in whom LVEF deteriorated. Using cardiorespiratory polygraphy recordings, cycle length (CL), apnea length (AL), ventilation length (VL), time to peak ventilation (TTPV), circulatory delay (CD) and VL:AL ratio were determined. RESULTS: There was no relationship between AHI and impairment of LVEF, but the characteristics of CSR were related to LV function. Comparing the groups with the best LVEF (>50%) and the worst LVEF (<20%), there were significant increases in CL (49+/-17-86+/-23s), AL (21+/-9-31+/-10s), VL (28+/-10-55+/-17s), TTPV (19+/-5-32+/-11s), VL:AL ratio (1.5+/-0.4-1.9+/-0.7s) and CD (29+/-8-49+/-16s). In the subgroup of patients who were studied twice, improvement in EF was associated with a decrease in these parameters. CONCLUSION: The current classification of CSR in CHF patients using AHI may be overly simplistic. Parameters such as CL, VL, TTPV and CD are related to cardiac function and could potentially be used for disease monitoring.
Juliane Wedewardt; Thomas Bitter; Christian Prinz; Lothar Faber; Dieter Horstkotte; Olaf Oldenburg
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Publication Detail:
Type:  Journal Article     Date:  2010-01-12
Journal Detail:
Title:  Sleep medicine     Volume:  11     ISSN:  1878-5506     ISO Abbreviation:  Sleep Med.     Publication Date:  2010 Feb 
Date Detail:
Created Date:  2010-02-09     Completed Date:  2010-04-23     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100898759     Medline TA:  Sleep Med     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Copyright Information:
2009 Elsevier B.V. All rights reserved.
Dept. of Cardiology, Heart and Diabetes Centre North-Rhine Westphalia, Ruhr University Bochum, Bad Oeynhausen, Germany.
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MeSH Terms
Blood Gas Analysis
Cheyne-Stokes Respiration / etiology,  physiopathology*
Exercise Test
Heart Failure / complications*,  physiopathology
Middle Aged
Monitoring, Physiologic
Natriuretic Peptide, Brain / blood
Stroke Volume / physiology*
Ventricular Function, Left / physiology*
Whole-Body Counting
Reg. No./Substance:
114471-18-0/Natriuretic Peptide, Brain

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