Document Detail


Chest wall kinematics and respiratory muscle coordinated action during hypercapnia in healthy males.
MedLine Citation:
PMID:  14735363     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The present study was designed to verify whether during hypercapnic stimulation, as we had previously found during exercise or walking, the partitioning of the respiratory motor output is equally distributed to the muscles of chest wall compartments to assist diaphragm function. We studied chest wall kinematics and respiratory muscle recruitment in seven healthy men during rebreathing of a hypercapnic-hyperoxic gas mixture (CO(2) RT). Data were compared with those previously obtained during either cycling exercise or walking. The chest wall volume ( Vcw), assessed by optoelectronic plethysmography (OEP), was modeled as the sum of the volumes of the lung-apposed rib cage ( Vrc,p), diaphragm-apposed rib cage ( Vrc,a) and abdomen ( Vab). Esophageal ( Pes), gastric ( Pga) and transdiaphragmatic ( Pdi= Pga- Pes) pressures were simultaneously recorded. Velocity of shortening ( V') and power ( W'= Px V') of the diaphragm ( W'di), rib cage muscles ( W'rcm) and abdominal muscles ( W'abm) were also calculated. During CO(2) RT the progressive increase in end-inspiratory Vcw resulted from an increase in both end-inspiratory Vrc,p and Vrc,a, while the progressive decrease in end-expiratory Vcw was entirely due to the decrease in end-expiratory Vab. The increase in Vrc,p was proportionally slightly greater than that in Vrc,a. The end-inspiratory increase and end-expiratory decrease in Vcw were accounted for by inspiratory rib cage (RCM,i) and abdominal (ABM) muscle recruitment, respectively. W'di, W'rcm and W'abm progressively increased. However, while most of W'di was expressed in terms of velocity of shortening, most of W'rcm and W'abm was expressed as force or pressure. A comparison of CO(2) results with data obtained during exercise revealed: (1). a gradual vs. an immediate response, (2). a similar decrease in Vab,e and Pabm, (3). an apparent lack of any difference in ABM recruitment, (4). less gradual ABM relaxation, (5). no drop in Pdi but a similar Wdi change and decrease in pressure-to-velocity ratio of the diaphragm. We have found that in healthy humans: (1). the increased motor output with hypercapnia is equally distributed between RCM and ABM to minimize transdiaphragmatic pressure and (2). data on chest wall kinematics and respiratory muscle recruitment are only partly in line with those obtained during walking or cycling exercise.
Authors:
I Romagnoli; F Gigliotti; B Lanini; R Bianchi; N Soldani; M Nerini; R Duranti; G Scano
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Publication Detail:
Type:  Clinical Trial; Journal Article     Date:  2004-01-21
Journal Detail:
Title:  European journal of applied physiology     Volume:  91     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2004 May 
Date Detail:
Created Date:  2004-04-16     Completed Date:  2004-11-30     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  525-33     Citation Subset:  IM    
Affiliation:
Fondazione Don C. Gnocchi IRCCS, Settore di Riabilitazione Respiratoria, Centro di S. Maria agli Ulivi, 50020 Pozzolatico (FI), Italy.
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MeSH Terms
Descriptor/Qualifier:
Abdominal Muscles / physiology*
Adult
Humans
Hypercapnia / physiopathology*
Male
Postural Balance / physiology*
Pulmonary Ventilation / physiology*
Respiratory Mechanics / physiology*
Respiratory Muscles / physiology*
Thoracic Wall / physiology*

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