Document Detail

Chest radiographic and CT manifestations of chronic granulomatous disease in adults.
MedLine Citation:
PMID:  18941103     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The purpose of this study was to describe the thoracic radiologic findings of chronic granulomatous disease in adults. MATERIALS AND METHODS: We retrospectively analyzed the chest radiographic and CT findings in four adults with chronic granulomatous disease during five episodes of lower respiratory tract infection. RESULTS: Chest radiographic findings included areas of consolidation (60%), diffuse reticulonodular opacities (40%), pleural effusion (20%), and pulmonary artery enlargement (20%). CT findings included areas of consolidation (60%), pulmonary nodules in a random distribution (60%), centrilobular nodules (60%), tree-in-bud opacities (40%), areas of scarring and traction bronchiectasis (100%), emphysematous changes (75%), areas of decreased attenuation and vascularity associated with air trapping on expiratory CT (50%), mediastinal and/or hilar lymphadenopathy (60%), pulmonary artery enlargement (50%), and pleural effusion (20%). Areas of consolidation and nodules were the most prominent findings and at histologic examination were found to be associated with infection or granulomatous inflammation. CONCLUSION: The pulmonary radiologic findings of chronic granulomatous disease include consolidation, nodules, areas of scarring, traction bronchiectasis, emphysema, air trapping, mediastinal and hilar lymphadenopathy, pulmonary artery enlargement, and pleural effusion.
Myrna C B Godoy; Patrick M Vos; Peter L Cooperberg; Carmen P Lydell; Peter Phillips; Nestor L Müller
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  AJR. American journal of roentgenology     Volume:  191     ISSN:  1546-3141     ISO Abbreviation:  AJR Am J Roentgenol     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-22     Completed Date:  2008-11-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7708173     Medline TA:  AJR Am J Roentgenol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1570-5     Citation Subset:  AIM; IM    
Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, BC, Canada.
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MeSH Terms
Granulomatous Disease, Chronic / radiography*
Pneumonia, Bacterial / radiography*
Radiography, Thoracic / methods*
Tomography, X-Ray Computed / methods*

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