Document Detail

Cherry consumption and decreased risk of recurrent gout attacks.
MedLine Citation:
PMID:  23023818     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: To study the relationship between cherry intake and the risk of recurrent gout attacks among individuals with gout.
METHODS: We conducted a case-crossover study to examine the associations of a set of putative risk factors with recurrent gout attacks. Individuals with gout were prospectively recruited and followed up online for 1 year. Participants were asked to provide the following information regarding gout attacks: the onset date of the gout attack, symptoms and signs, medications (including antigout medications), and exposure to potential risk factors (including daily intake of cherries and cherry extract) during the 2-day period prior to the gout attack. We assessed the same exposure information over 2-day control periods. We estimated the risk of recurrent gout attacks related to cherry intake using conditional logistic regression. Odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated.
RESULTS: Our study included 633 individuals with gout. Cherry intake over a 2-day period was associated with a 35% lower risk of gout attacks compared with no intake (multivariate OR 0.65 [95% CI 0.50-0.85]). Cherry extract intake showed a similar inverse association (multivariate OR 0.55 [95% CI 0.30-0.98]). The effect of cherry intake persisted across subgroups stratified by sex, obesity status, purine intake, alcohol use, diuretic use, and use of antigout medications. When cherry intake was combined with allopurinol use, the risk of gout attacks was 75% lower than during periods without either exposure (OR 0.25 [95% CI 0.15-0.42]).
CONCLUSION: These findings suggest that cherry intake is associated with a lower risk of gout attacks.
Yuqing Zhang; Tuhina Neogi; Clara Chen; Christine Chaisson; David J Hunter; Hyon K Choi
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Arthritis and rheumatism     Volume:  64     ISSN:  1529-0131     ISO Abbreviation:  Arthritis Rheum.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-29     Completed Date:  2013-04-02     Revised Date:  2014-01-06    
Medline Journal Info:
Nlm Unique ID:  0370605     Medline TA:  Arthritis Rheum     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4004-11     Citation Subset:  AIM; IM    
Copyright Information:
Copyright © 2012 by the American College of Rheumatology.
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MeSH Terms
Aged, 80 and over
Alcohol Drinking / epidemiology
Cross-Over Studies
Follow-Up Studies
Gout / drug therapy,  epidemiology*,  prevention & control*
Gout Suppressants / therapeutic use
Middle Aged
Obesity / epidemiology
Prospective Studies
Risk Factors
Sex Factors
Grant Support
Reg. No./Substance:
0/Gout Suppressants
Comment In:
Evid Based Med. 2013 Dec;18(6):230-1   [PMID:  23416419 ]
Arthritis Rheum. 2012 Dec;64(12):3827-30   [PMID:  23023794 ]
Nat Rev Rheumatol. 2012 Nov;8(11):634   [PMID:  23070642 ]
Arthritis Rheum. 2013 Apr;65(4):1135-6   [PMID:  23334899 ]

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