Document Detail

Chemotherapy versus self-expanding metal stent as primary treatment of severe dysphagia from unresectable oesophageal or gastro-oesophageal junction cancer.
MedLine Citation:
PMID:  24268567     Owner:  NLM     Status:  Publisher    
OBJECTIVE: To compare chemotherapy first (group 1) versus self-expanding metal stent first (group 2) for the management of malignant dysphagia in unresectable oesophageal or gastro-oesophageal junction cancer.
METHODS: Patients from two university hospitals with severe malignant dysphagia (dysphagia score≥2) uneligible for surgery or radiochemotherapy were evaluated retrospectively.
RESULTS: Forty-two patients were included in group 1, and 29 in group 2. After 4 weeks, dysphagia scores improved by at least 1 point in 67% of patients in group 1 versus 93% in group 2 (p=0.01); 48% of patients in group 1 were able to eat solid food versus 68% in group 2 (p=0.054). In group 1, a self-expanding metal stent was secondarily placed in 18 patients (42.9%), whereas in group 2 dysphagia required a second self-expanding metal stent placement in 33.3% of patients.
CONCLUSION: Chemotherapy as the first treatment may be a valid option, avoiding self-expanding metal stent insertion in half of the patients.
Yann Touchefeu; Isabelle Archambeaud; Bruno Landi; Astrid Lièvre; Céline Lepère; Philippe Rougier; Emmanuel Mitry
Related Documents :
24279607 - Long-term clinical results on the use of platelet concentrate in the treatment of intra...
24918567 - Efficacy and safety of ingenol mebutate 0.015% gel after cryosurgery of actinic keratos...
9870617 - The non-specific effect of endolymphatic sac surgery in treatment of meniere's disease:...
17114147 - 15-year prospective follow-up study of behavioral therapy in a large sample of inpatien...
16943997 - Open, preperitoneal hernia repair with the kugel patch: a prospective, multicentre stud...
19888357 - Sequential comparison of tiotropium to high-dose ipratropium in patients with chronic o...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-20
Journal Detail:
Title:  Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver     Volume:  -     ISSN:  1878-3562     ISO Abbreviation:  Dig Liver Dis     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100958385     Medline TA:  Dig Liver Dis     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.
Institut des Maladies de l'Appareil Digestif, Gastrointestinal Oncology Unit, University Hospital, Nantes Cedex 1, France. Electronic address:
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Radiotherapy for sinonasal undifferentiated carcinoma.
Next Document:  Low incidence but poor prognosis of complicated coeliac disease: A retrospective multicentre study.